BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process.

IF 5.7 2区医学 Q1 Medicine

Cancer Science Pub Date : 2024-09-24 DOI:10.1111/cas.16350

Wenxu Zou, Qing Yin, Wei Guo, Zhiming Dong, Yanli Guo

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Abstract

It is recognized that lncRNA BBOX1-AS1 exerts a crucial oncogenic property in several cancer types. However, the functions and underlying mechanisms of BBOX1-AS1 in the epithelial-mesenchymal transition (EMT) process of gastric cardia adenocarcinoma (GCA) have remained unclarified. The findings of this study demonstrated that GCA tissues had elevated BBOX1-AS1 expression levels, which was associated with a worse prognosis in GCA patients. BBOX1-AS1 dramatically enhanced cell proliferation, invasion, and TGF-β1-induced the EMT process in vitro. Further mechanism analysis revealed that BBOX1-AS1 could combine with CtBP2 and strengthen the interaction of CtBP2 and ZEB1. BBOX1-AS1 might regulate the E-cadherin expression through CtBP2/ZEB1 transcriptional complex-mediated transcriptional repression, further affecting the activation of the Wnt/β-catenin pathway and the EMT process. Overall, our findings demonstrate that BBOX1-AS1 might act as an lncRNA associated with EMT for facilitating GCA advancement via interaction with CtBP2 to facilitate the activation of Wnt/β-catenin pathway and the EMT process, which indicated that it might function as an exploitable treatment target for GCA patients.

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BBOX1-AS1通过与CtBP2相互作用促进上皮-间质转化过程，从而促进胃贲门腺癌的进展。

人们已经认识到，lncRNA BBOX1-AS1在多种癌症类型中具有关键的致癌特性。然而，BBOX1-AS1在胃贲门腺癌（GCA）上皮-间质转化（EMT）过程中的功能和内在机制仍未明确。本研究结果表明，GCA 组织中 BBOX1-AS1 表达水平升高，这与 GCA 患者预后较差有关。在体外，BBOX1-AS1能显著增强细胞增殖、侵袭和TGF-β1诱导的EMT过程。进一步的机制分析表明，BBOX1-AS1可与CtBP2结合，并加强CtBP2与ZEB1的相互作用。BBOX1-AS1可能通过CtBP2/ZEB1转录复合物介导的转录抑制调控E-cadherin的表达，进一步影响Wnt/β-catenin通路的激活和EMT过程。总之，我们的研究结果表明，BBOX1-AS1可能是一种与EMT相关的lncRNA，通过与CtBP2相互作用，促进Wnt/β-catenin通路的激活和EMT过程，从而促进GCA的进展，这表明它可能成为GCA患者的一个可利用的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.