CircRNA and lncRNA-encoded peptide in diseases, an update review

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-09-30 DOI:10.1186/s12943-024-02131-7

Qian Yi, Jianguo Feng, Weiwu Lan, Houyin shi, Wei Sun, Weichao Sun

引用次数: 0

Abstract

Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), are unique RNA molecules widely identified in the eukaryotic genome. Their dysregulation has been discovered and played key roles in the pathogenesis of numerous diseases, including various cancers. Previously considered devoid of protein-coding ability, recent research has revealed that a small number of open reading frames (ORFs) within these ncRNAs endow them with the potential for protein coding. These ncRNAs-derived peptides or proteins have been proven to regulate various physiological and pathological processes through diverse mechanisms. Their emerging roles in disease diagnosis and targeted therapy underscore their potential utility in clinical settings. This comprehensive review aims to provide a systematic overview of proteins or peptides encoded by lncRNAs and circRNAs, elucidate their production and functional mechanisms, and explore their promising applications in cancer diagnosis, disease prediction, and targeted therapy.

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疾病中的 CircRNA 和 lncRNA 编码肽：最新综述

非编码 RNA（ncRNA），包括环状 RNA（circRNA）和长非编码 RNA（lncRNA），是真核生物基因组中广泛存在的独特 RNA 分子。它们的失调已被发现，并在包括各种癌症在内的多种疾病的发病机制中发挥了关键作用。以前人们认为这些 ncRNA 不具备编码蛋白质的能力，但最近的研究发现，这些 ncRNA 中的少量开放阅读框（ORF）赋予了它们编码蛋白质的潜力。这些 ncRNA 衍生的多肽或蛋白质已被证实可通过不同机制调节各种生理和病理过程。它们在疾病诊断和靶向治疗中新出现的作用凸显了它们在临床中的潜在用途。本综述旨在系统地概述由 lncRNAs 和 circRNAs 编码的蛋白质或多肽，阐明它们的产生和功能机制，并探讨它们在癌症诊断、疾病预测和靶向治疗中的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.