Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?

IF 14.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Kathryn G. Leslie, Sian S. Berry, Gavin J. Miller, Clare S. Mahon
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Abstract

Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the assembly of multivalent glycoconjugates means it is possible to create synthetic systems that more and more closely resemble the diversity and complexity we observe in nature. In this Perspective we present the background to the recognition and binding enabled by multivalent interactions in nature, and discuss the strategies used to construct synthetic glycoconjugate equivalents. We highlight key discoveries and the current state of the art in their applications to glycan arrays, vaccines, and other therapeutic and diagnostic tools, with an outlook toward some areas we believe are of most interest for future work in this area.

Abstract Image

糖衣:多价糖共轭物能否改进大自然的设计?
受体与聚糖之间的多价相互作用在病原体感染、自我识别和免疫反应等许多不同的生物过程中发挥着重要作用。组装多价糖结合体的工具和技术越来越多,这意味着有可能创造出越来越接近我们在自然界中观察到的多样性和复杂性的合成系统。在本《视角》中,我们介绍了自然界中多价相互作用促成的识别和结合的背景,并讨论了用于构建合成等价糖结合物的策略。我们将重点介绍在聚糖阵列、疫苗及其他治疗和诊断工具应用方面的主要发现和技术现状,并对我们认为该领域未来工作最感兴趣的一些领域进行展望。
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来源期刊
CiteScore
24.40
自引率
6.00%
发文量
2398
审稿时长
1.6 months
期刊介绍: The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.
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