Association between the C-reactive protein to albumin ratio and poor clinical outcome in patients with spontaneous intracerebral hemorrhage

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2024-09-24 DOI:10.1016/j.jstrokecerebrovasdis.2024.108026

Yang Du MD , Yijun Lin MD , Anxin Wang PHD , Jia Zhang MD , Ning Li MD , Xiaoli Zhang BS , Xinmin Liu MD , Dandan Wang MD , Wenjuan Wang MD , Xingquan Zhao MD, PHD , Liheng Bian MD

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引用次数: 0

Abstract

Background

The C-reactive protein-to-albumin ratio (CAR) is a novel prognostic biomarker of systemic inflammation and nutritional status. The association between CAR and the long-term outcome of spontaneous intracerebral hemorrhage (ICH) remains unclear.

Methods

From January 2014 to September 2016, 497 patients with spontaneous ICH were enrolled in our study from 13 hospitals in Beijing. According to the CAR quartiles, patients were classified into four groups (Q1-Q4). Logistic regression was applied to analyze the relationship between different CAR levels and main outcome (90-day and 1-year mRS 4-6). Restricted cubic splines and receiver operating characteristic (ROC) curves of CAR for poor clinical outcomes were assessed.

Results

In the multivariate logistic regression model, compared with the lowest quartile of CAR, the adjusted odds ratios of the Q2, Q3, and Q4 group for 90-day mRS score of 4-6 were 3.64 (1.61–8.23), 3.83 (1.67–8.77), and 8.91 (3.85–20.64). In terms of 1-year mRS score of 4-6, compared with the lowest quartile of CAR, the adjusted odds ratios of the Q3 and Q4 group were 3.31 (1.33–8.22) and 6.87 (2.81–16.78).

Conclusions

A high CAR level was associated with a high risk of long-term adverse prognosis in patients with ICH, and the risk of ICH poor outcome increased steadily with CAR rising in a certain range, and maintained in a high level thereafter.

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自发性脑出血患者的 C 反应蛋白与白蛋白比率与不良临床预后之间的关系

背景C反应蛋白-白蛋白比值（CAR）是全身炎症和营养状况的新型预后生物标志物。方法从 2014 年 1 月至 2016 年 9 月，我们从北京 13 家医院招募了 497 例自发性 ICH 患者。根据 CAR 四分位数将患者分为四组（Q1-Q4）。应用逻辑回归分析不同 CAR 水平与主要结局（90 天和 1 年 mRS 4-6）之间的关系。结果在多变量逻辑回归模型中，与最低四分位数的 CAR 相比，Q2、Q3 和 Q4 组 90 天 mRS 评分为 4-6 分的调整赔率分别为 3.64（1.61-8.23）、3.83（1.67-8.77）和 8.91（3.85-20.64）。结论高水平的 CAR 与 ICH 患者长期不良预后的高风险相关，ICH 不良预后的风险随着 CAR 在一定范围内的升高而稳步增加，并在此后保持在高水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.