Reduced-distortion diffusion weighted imaging for head and neck radiotherapy

IF 3.4 Q2 ONCOLOGY
Eric Aliotta , Ramesh Paudyal , Alex Dresner , Amita Shukla-Dave , Nancy Lee , Laura Cerviño , Ricardo Otazo , Victoria Y. Yu
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引用次数: 0

Abstract

Background and purpose

Quantitative Diffusion Weighted Imaging (DWI) has potential value in guiding head and neck (HN) cancer radiotherapy. However, clinical translation has been hindered by severe distortions in standard single-shot Echo-Planar-Imaging (ssEPI) and prolonged scan time and low SNR in Turbo-Spin-Echo (ssTSE) sequences. In this study, we evaluate “multi-shot” (ms) msEPI and msTSE acquisitions in the context of HN radiotherapy.

Materials and methods

ssEPI, ssTSE, msEPI with 2 and 3 shots (2sEPI, 3sEPI), and msTSE DWI were acquired in a phantom, healthy volunteers (N=10), and patients with HN cancer (N=5) on a 3-Tesla wide-bore MRI in radiotherapy simulation RF coil setup, with matched spatial resolution (2x2x5mm) and b = 0, 200, 800 s/mm2.
Geometric distortions measured with deformable vector field (DVF) and contour analysis, apparent diffusion coefficient (ADC) values, and signal-to-noise-ratio efficiency (SNReff) were quantified for all scans.

Results

All techniques significantly (P<1x10-3) reduced distortions compared with ssEPI (DVFmean = 3.1 ± 1.3 mm). Distortions were marginally lower for msTSE (DVFmean = 1.5 ± 0.6 mm) than ssTSE (1.8 ± 0.9 mm), but were slightly higher with 2sEPI and 3sEPI (2.6 ± 1.0 mm, 2.2 ± 1.0 mm). SNReff reduced with decreasing distortion with ssEPI=21.9 ± 7.9, 2sEPI=15.1 ± 5.0, 3sEPI=12.1 ± 4.5, ssTSE=6.0 ± 1.6, and msTSE=5.7 ± 1.9 for b = 0 images. Phantom ADC values were consistent across all protocols (errors ≤ 0.03x10-3mm2/s), but in vivo ADC values were ∼ 4 % lower with msEPI and ∼ 12 % lower with ssTSE/msTSE compared with ssEPI.

Conclusions

msEPI and TSE acquisitions exhibited improved geometric distortion at the cost of SNReff and scan time. While msTSE exhibited the least distortion, 3sEPI may offer an appealing middle-ground with improved geometric fidelity but superior efficiency and in vivo ADC quantification.
用于头颈部放射治疗的降低失真扩散加权成像技术
背景和目的定量弥散加权成像(DWI)在指导头颈部癌症放疗方面具有潜在价值。然而,标准单次回波-平面成像(ssEPI)的严重失真以及涡轮螺旋回波(ssTSE)序列的扫描时间长和信噪比低阻碍了临床应用。在本研究中,我们评估了在 HN 放射治疗中的 "多拍"(ms)msEPI 和 msTSE 采集。材料和方法:在放疗模拟射频线圈设置的 3-Tesla 宽孔径 MRI 上,以匹配的空间分辨率(2x2x5mm)和 b = 0、200、800 s/mm2 对模型、健康志愿者(10 人)和 HN 癌症患者(5 人)进行了 mssEPI、ssTSE、2 次和 3 次 msEPI(2sEPI、3sEPI)以及 msTSE DWI 采集。用可变形矢量场(DVF)和轮廓分析测量的几何失真、表观扩散系数(ADC)值和信噪比效率(SNReff)对所有扫描进行了量化。结果与 ssEPI 相比,所有技术都能显著(P<1x10-3)减少失真(DVF 平均值 = 3.1 ± 1.3 mm)。msTSE 的失真(DVFmean = 1.5 ± 0.6 mm)略低于 ssTSE(1.8 ± 0.9 mm),但略高于 2sEPI 和 3sEPI(2.6 ± 1.0 mm、2.2 ± 1.0 mm)。对于 b = 0 的图像,SNReff 随畸变的减小而降低,ssEPI=21.9 ± 7.9,2sEPI=15.1 ± 5.0,3sEPI=12.1 ± 4.5,ssTSE=6.0 ± 1.6,msTSE=5.7 ± 1.9。所有方案的模拟 ADC 值都一致(误差≤ 0.03x10-3mm2/s),但与 ssEPI 相比,msEPI 的体内 ADC 值低 4%,ssTSE/msTSE 的体内 ADC 值低 12%。msTSE的失真最小,而3sEPI可能是一种有吸引力的中间方案,其几何保真度更高,但效率和体内ADC定量更优。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
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