Humans without GDF15 reassure drug developers

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-09-26 DOI:10.1038/s42255-024-01136-2

Samuel N. Breit, Stephen O’Rahilly

引用次数: 0

Abstract

In this issue of Nature Metabolism, nine people lacking growth differentiation factor 15 (GDF15) from conception are shown to be healthy, with normal development and fertility, providing some reassurance about the safety of blocking GDF15 in conditions like cachexia and pregnancy sickness, where GDF15 contributes to disease pathogenesis.

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不含 GDF15 的人类让药物开发人员放心

在本期《自然-新陈代谢》（Nature Metabolism）杂志上，9名从受孕起就缺乏生长分化因子15（GDF15）的人被证明身体健康，发育和生育能力正常，这为在恶病质和妊娠病等疾病中阻断GDF15的安全性提供了一些保证，因为GDF15在这些疾病的发病机制中起着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.