Universal and tissue-specific fibroblasts in chronic inflammation and cancer

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-26 DOI:10.1016/j.ccell.2024.08.022

Simon Koplev, Sarah A. Teichmann

引用次数: 0

Abstract

In this issue of Cancer Cell, Gao et al. map fibroblast diversity across tumors and chronic inflammatory tissues. The authors uncover universal fibroblast subtypes such as LRRC15⁺ and MMP1⁺ myofibroblasts along with specialized tissue-specific subtypes. They reveal cellular roles of fibroblasts in immunosuppression through stromal niches and cell-cell interactions.

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慢性炎症和癌症中的通用和组织特异性成纤维细胞

在本期《癌细胞》（Cancer Cell）杂志上，Gao 等人绘制了肿瘤和慢性炎症组织中成纤维细胞的多样性图谱。作者发现了普遍的成纤维细胞亚型，如 LRRC15+ 和 MMP1+ 肌成纤维细胞，以及专门的组织特异性亚型。他们揭示了成纤维细胞通过基质壁龛和细胞-细胞相互作用在免疫抑制中的细胞作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.