Admixture in the fungal pathogen Blastomyces.

IF 3.3 3区生物学 Q2 GENETICS & HEREDITY

Genetics Pub Date : 2024-09-24 DOI:10.1093/genetics/iyae155

Gaston I Jofre, Andrius J Dagilis, Victoria E Sepúlveda, Tayte Anspach, Ashutosh Singh, Anuradha Chowdhary, Daniel R Matute

引用次数: 0

Abstract

Blastomyces is an emerging primary fungal pathogen that affects patients worldwide. The evolutionary processes that have resulted in the current diversity in the genus remain largely unexplored. We used whole genome sequences from 99 Blastomyces isolates, including two sequenced in this study using long-read technologies, to infer the phylogenetic relationships between Blastomyces species. We find that five different methods infer five different phylogenetic trees. Additionally, we find gene tree discordance along the genome with differences in the relative phylogenetic placement of several species of Blastomyces, which we hypothesize is caused by introgression. Our results suggest the urgent need to systematically collect Blastomyces samples around the world and study the evolutionary processes that govern intra- and interspecific variation in these medically important fungi.

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真菌病原体 Blastomyces 中的混合物。

子囊菌是一种新出现的主要真菌病原体，影响着世界各地的患者。导致该属目前多样性的进化过程在很大程度上仍未得到探索。我们利用来自 99 个分离出的高真菌的全基因组序列（包括本研究中利用长读取技术测序的两个序列）来推断高真菌物种之间的系统发育关系。我们发现，五种不同的方法推断出了五种不同的系统发生树。此外，我们还发现基因组中的基因树不一致，几个种的相对系统发育位置也有差异，我们推测这是由于引种造成的。我们的研究结果表明，迫切需要在全球范围内系统性地采集子囊菌样本，并研究这些在医学上具有重要意义的真菌种内和种间变异的进化过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics GENETICS & HEREDITY-

CiteScore

6.90

自引率

6.10%

发文量

177

审稿时长

1.5 months

期刊介绍： GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.