Jong-Ha Baek, Yong Zhu, Chandra L Jackson, Yong-Moon Mark Park
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引用次数: 0
Abstract
The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor of natural circadian rhythms, potentially leading to a rise in unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon has been associated with an increased risk of type 2 diabetes mellitus (T2DM), which is a pressing global public health concern. However, to date, reviews summarizing associations between ALAN and T2DM have primarily focused on the limited characteristics of exposure (e.g., intensity) to ALAN. This literature review extends beyond prior reviews by consolidating recent studies from 2000 to 2024 regarding associations between both indoor and outdoor ALAN exposure and the incidence or prevalence of T2DM. We also described potential biological mechanisms through which ALAN modulates glucose metabolism. Furthermore, we outlined knowledge gaps and investigated how various ALAN characteristics beyond only light intensity (including light type, timing, duration, wavelength, and individual sensitivity) influence T2DM risk. Recognizing the detrimental impact of ALAN on sleep health and the behavioral correlates of physical activity and dietary patterns, we additionally summarized studies investigating the potential mediating role of each component in the relationship between ALAN and glucose metabolism. Lastly, we proposed implications of chronotherapies and chrononutrition for diabetes management in the context of ALAN exposure.
在现代 24 小时社会中,夜间人造光(ALAN)的广泛和普遍使用已成为自然昼夜节律的重要干扰因素,有可能导致与生活方式相关的不健康行为(如睡眠质量差、轮班工作)增加。这种现象与罹患 2 型糖尿病(T2DM)的风险增加有关,而 2 型糖尿病是一个紧迫的全球公共健康问题。然而,迄今为止,总结 ALAN 与 T2DM 之间关系的综述主要集中于 ALAN 暴露的有限特征(如强度)。本文献综述超越了以往的综述,整合了从 2000 年到 2024 年有关室内和室外 ALAN 暴露与 T2DM 发病率或患病率之间关系的最新研究。我们还描述了 ALAN 调节葡萄糖代谢的潜在生物机制。此外,我们还概述了知识空白,并研究了除光照强度之外的各种 ALAN 特性(包括光照类型、时间、持续时间、波长和个体敏感性)如何影响 T2DM 风险。考虑到 ALAN 对睡眠健康的不利影响以及体育锻炼和饮食模式的行为相关性,我们还总结了有关 ALAN 和糖代谢之间关系中各组成部分潜在中介作用的研究。最后,我们提出了在暴露于 ALAN 的情况下,慢性疗法和慢性营养对糖尿病管理的影响。
期刊介绍:
The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies.
The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication.
The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.