The Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study.

Psychopharmacology bulletin Pub Date : 2024-08-19
Alexa O Levey, Grant H Chen, Alexandra Ngyuen, Luis Ostrosky-Zeichner, Jamal Hasoon, Sepideh Saroukhani, Matthew Lin
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Abstract

Purpose: Pilot study to evaluate the safety and effectiveness of stellate ganglion blocks in the treatment of symptoms related to long COVID infection.

Materials and methods: A total of 17 patients who underwent stellate ganglion block for the treatment of their long COVID symptoms were included. COMPASS-31, GAD-7, PCL-5, and Fatigue Severity Score (FSS) pre and post intervention surveys and data on baseline heartrate and post- block heart rate recorded in the EMR.

Results: A total of 94% of patients reported moderate-to-severe autonomic dysfunction pre-procedure as measured by COMPASS-31. All patients reported some degree of symptomatic improvement from the block. Specifically, patients had significantly lower FSS scores (P = 0.002) and heart rate post-procedure (P = 0.008). Although the decrease in PCL-5 scores after the procedure was clinically meaningful, this change was not statistically significant (P = 0.159). No significant difference was found in pre and post procedure GAD-7 scores (P = 0.101).

Conclusions: Stellate ganglion block is a safe, low-risk, minimally invasive, and effective procedure in the treatment of symptoms for long COVID. It should be evaluated as an adjunctive treatment of select patients in this population.

星状神经节阻滞治疗长 COVID-19 症状的有效性和安全性:一项试点研究。
目的:评估星状神经节阻滞治疗长COVID感染相关症状的安全性和有效性的试验性研究:共纳入了17名接受星状神经节阻滞治疗长COVID症状的患者。干预前后的 COMPASS-31、GAD-7、PCL-5 和疲劳严重程度评分(FSS)调查以及 EMR 中记录的基线心率和阻滞后心率数据:根据 COMPASS-31 测量,共有 94% 的患者在术前报告了中度至重度自主神经功能障碍。所有患者均报告阻滞后症状有一定程度的改善。具体来说,患者的 FSS 评分(P = 0.002)和术后心率(P = 0.008)明显降低。虽然手术后 PCL-5 评分的下降具有临床意义,但这一变化在统计学上并不显著(P = 0.159)。手术前后的 GAD-7 评分无明显差异(P = 0.101):结论:星状神经节阻滞是一种安全、低风险、微创且有效的治疗长 COVID 症状的方法。结论:星状神经节阻滞是治疗长 COVID 症状的一种安全、低风险、微创且有效的方法,应将其作为此类人群中特定患者的辅助治疗方法进行评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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