Evaluation of the influenza-like illness case definition and the acute respiratory infection case definition in the diagnosis of influenza and COVID-19 in healthcare personnel

IF 2.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Infection Disease & Health Pub Date : 2025-02-01 DOI:10.1016/j.idh.2024.08.002

Helena C. Maltezou , Flora Sourri , Nikolaos Lemonakis , Amalia Karapanou , Theodoros V. Giannouchos , Maria N. Gamaletsou , Dimitra-Maria Koukou , Kyriakos Souliotis , Athanasia Lourida , Periklis Panagopoulos , Dimitrios Hatzigeorgiou , Nikolaos V. Sipsas

{"title":"Evaluation of the influenza-like illness case definition and the acute respiratory infection case definition in the diagnosis of influenza and COVID-19 in healthcare personnel","authors":"Helena C. Maltezou , Flora Sourri , Nikolaos Lemonakis , Amalia Karapanou , Theodoros V. Giannouchos , Maria N. Gamaletsou , Dimitra-Maria Koukou , Kyriakos Souliotis , Athanasia Lourida , Periklis Panagopoulos , Dimitrios Hatzigeorgiou , Nikolaos V. Sipsas","doi":"10.1016/j.idh.2024.08.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the influenza-like illness (ILI) and acute respiratory infection (ARI) case definitions in the diagnosis of COVID-19 and influenza in healthcare personnel (HCP).</div></div><div><h3>Methods</h3><div>We followed a cohort of 5752 HCP from November 2022 to May 2023. Symptomatic HCP were tested for SARS-CoV-2 and influenza by real-time PCR and/or rapid antigen detection test. ILI was defined as the sudden onset of ≥1 systemic symptom and ≥1 respiratory symptom. ARI was defined as the sudden onset of ≥1 respiratory symptom. Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.</div></div><div><h3>Results</h3><div>Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23–78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88–3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. ILI and ARI had an overall correct classification rate of 89.6% and 74.1%, respectively.</div></div><div><h3>Conclusion</h3><div>Our findings support the use of both ILI and ARI case definitions in the diagnosis of influenza and COVID-19 in HCP.</div></div>","PeriodicalId":45006,"journal":{"name":"Infection Disease & Health","volume":"30 1","pages":"Pages 23-27"},"PeriodicalIF":2.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Disease & Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468045124000658","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Background

To evaluate the influenza-like illness (ILI) and acute respiratory infection (ARI) case definitions in the diagnosis of COVID-19 and influenza in healthcare personnel (HCP).

Methods

We followed a cohort of 5752 HCP from November 2022 to May 2023. Symptomatic HCP were tested for SARS-CoV-2 and influenza by real-time PCR and/or rapid antigen detection test. ILI was defined as the sudden onset of ≥1 systemic symptom and ≥1 respiratory symptom. ARI was defined as the sudden onset of ≥1 respiratory symptom. Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.

Results

Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23–78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88–3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. ILI and ARI had an overall correct classification rate of 89.6% and 74.1%, respectively.

Conclusion

Our findings support the use of both ILI and ARI case definitions in the diagnosis of influenza and COVID-19 in HCP.

查看原文本刊更多论文

评估医护人员在诊断流感和 COVID-19 时采用的流感样病例定义和急性呼吸道感染病例定义。

背景：评估医护人员在诊断 COVID-19 和流感时对流感样疾病（ILI）和急性呼吸道感染（ARI）病例的定义：评估医护人员（HCP）在诊断COVID-19和流感时的流感样疾病（ILI）和急性呼吸道感染（ARI）病例定义：方法：我们从 2022 年 11 月至 2023 年 5 月对 5752 名医护人员进行了追踪调查。通过实时 PCR 和/或快速抗原检测试验对有症状的医护人员进行了 SARS-CoV-2 和流感检测。ILI定义为突然出现≥1种全身症状和≥1种呼吸道症状。ARI是指突然出现≥1种呼吸道症状。根据发热、乏力、头痛和/或肌痛的存在情况，将有呼吸道症状的患者归为 ILI 或 ARI：总共有 466 例 ILI 和 383 例 ARI。患流感性咽喉炎的住院病人被诊断为流感的调整赔率（aOR）为 22.05 [95%置信区间（CI）：6.23-78.04]。患有急性呼吸道感染的人类接触者被诊断为 COVID-19 的 aOR 为 2.70（95% 置信区间：1.88-3.88）。流感 ILI 的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为 96.6%、49.9%、18.2% 和 99.2%。COVID-19对ARI的敏感性、特异性、PPV和NPV分别为51.7%、73.6%、84.9%和34.8%。ILI和ARI的总体分类正确率分别为89.6%和74.1%：我们的研究结果支持使用 ILI 和 ARI 病例定义来诊断高危人群中的流感和 COVID-19。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Infection Disease & Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

5.70

自引率

5.70%

发文量

审稿时长

20 days

期刊介绍： The journal aims to be a platform for the publication and dissemination of knowledge in the area of infection and disease causing infection in humans. The journal is quarterly and publishes research, reviews, concise communications, commentary and other articles concerned with infection and disease affecting the health of an individual, organisation or population. The original and important articles in the journal investigate, report or discuss infection prevention and control; clinical, social, epidemiological or public health aspects of infectious disease; policy and planning for the control of infections; zoonoses; and vaccination related to disease in human health. Infection, Disease & Health provides a platform for the publication and dissemination of original knowledge at the nexus of the areas infection, Disease and health in a One Health context. One Health recognizes that the health of people is connected to the health of animals and the environment. One Health encourages and advances the collaborative efforts of multiple disciplines-working locally, nationally, and globally-to achieve the best health for people, animals, and our environment. This approach is fundamental because 6 out of every 10 infectious diseases in humans are zoonotic, or spread from animals. We would be expected to report or discuss infection prevention and control; clinical, social, epidemiological or public health aspects of infectious disease; policy and planning for the control of infections; zoonosis; and vaccination related to disease in human health. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in this ever-changing field. The audience of the journal includes researchers, clinicians, health workers and public policy professionals concerned with infection, disease and health.