Li-Wei Kuo, Lyndsey S Crump, Kathleen O'Neill, Michelle M Williams, Jessica L Christenson, Nicole S Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A Reisz, Angelo D'Alessandro, Meher P Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G Bitler, Jennifer K Richer
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Abstract
Significance: TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.
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