{"title":"Interpretable discriminant analysis for functional data supported on random nonlinear domains with an application to Alzheimer's disease.","authors":"Eardi Lila, Wenbo Zhang, Swati Rane Levendovszky","doi":"10.1093/jrsssb/qkae023","DOIUrl":null,"url":null,"abstract":"<p><p>We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their cortical surface geometry and associated cortical thickness map. The proposed model is based upon a reformulation of the classification problem as a regularized multivariate functional linear regression model. This allows us to adopt a direct approach to the estimation of the most discriminant direction while controlling for its complexity with appropriate differential regularization. Our approach does not require prior estimation of the covariance structure of the functional predictors, which is computationally prohibitive in our application setting. We provide a theoretical analysis of the out-of-sample prediction error of the proposed model and explore the finite sample performance in a simulation setting. We apply the proposed method to a pooled dataset from Alzheimer's Disease Neuroimaging Initiative and Parkinson's Progression Markers Initiative. Through this application, we identify discriminant directions that capture both cortical geometric and thickness predictive features of Alzheimer's disease that are consistent with the existing neuroscience literature.</p>","PeriodicalId":49982,"journal":{"name":"Journal of the Royal Statistical Society Series B-Statistical Methodology","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398888/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Royal Statistical Society Series B-Statistical Methodology","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1093/jrsssb/qkae023","RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
引用次数: 0
Abstract
We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their cortical surface geometry and associated cortical thickness map. The proposed model is based upon a reformulation of the classification problem as a regularized multivariate functional linear regression model. This allows us to adopt a direct approach to the estimation of the most discriminant direction while controlling for its complexity with appropriate differential regularization. Our approach does not require prior estimation of the covariance structure of the functional predictors, which is computationally prohibitive in our application setting. We provide a theoretical analysis of the out-of-sample prediction error of the proposed model and explore the finite sample performance in a simulation setting. We apply the proposed method to a pooled dataset from Alzheimer's Disease Neuroimaging Initiative and Parkinson's Progression Markers Initiative. Through this application, we identify discriminant directions that capture both cortical geometric and thickness predictive features of Alzheimer's disease that are consistent with the existing neuroscience literature.
期刊介绍:
Series B (Statistical Methodology) aims to publish high quality papers on the methodological aspects of statistics and data science more broadly. The objective of papers should be to contribute to the understanding of statistical methodology and/or to develop and improve statistical methods; any mathematical theory should be directed towards these aims. The kinds of contribution considered include descriptions of new methods of collecting or analysing data, with the underlying theory, an indication of the scope of application and preferably a real example. Also considered are comparisons, critical evaluations and new applications of existing methods, contributions to probability theory which have a clear practical bearing (including the formulation and analysis of stochastic models), statistical computation or simulation where original methodology is involved and original contributions to the foundations of statistical science. Reviews of methodological techniques are also considered. A paper, even if correct and well presented, is likely to be rejected if it only presents straightforward special cases of previously published work, if it is of mathematical interest only, if it is too long in relation to the importance of the new material that it contains or if it is dominated by computations or simulations of a routine nature.