{"title":"Evaluation of fatigue and fatigability in people with Duchenne muscular dystrophy using a dynamic arm support - a pilot study.","authors":"Lonneke Alberts, Nicole Voet, Mariska Janssen","doi":"10.1080/17483107.2024.2388284","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Due to progressive muscle wasting and weakness in patients with Duchenne Muscular Dystrophy (DMD), physical fatigability increases, upper extremity function reduces, which negatively impacts quality of life. Assistive technology such as dynamic arm supports (DAS) may help reduce this fatigability. This study aims to assess whether the novel Yumen 'EXone' DAS can reduce upper extremity fatigue and fatigability in DMD patients and healthy controls (HC), both with and without the DAS. Additionally, longitudinal changes in DMD patients were evaluated.</p><p><strong>Methods: </strong>Five DMD patients from the Yumen Bionics pioneer program and five HCs participated. Two submaximal tests simulating drinking and reaching were performed for two minutes, each with and without DAS. DMD participants completed these tests twice, at baseline (T0) and after 6-9 months (T1), while HCs completed them once. Physical fatigability was measured by the number of repetitions and changes in surface electromyography (sEMG) amplitude. Subjective fatigue was assessed using the Borg Scale (6-20) Rate of Perceived Exertion (RPE).</p><p><strong>Results: </strong>DMD participants generally performed more repetitions with the DAS than without. HCs showed similar or increased repetitions with the DAS. Assessing fatigability with sEMG was difficult due to the compensatory mechanisms used for the tests. Subjective fatigue scores on the Borg Scale were lower with the DAS for both DMD patients and HCs.</p><p><strong>Conclusion: </strong>The Yumen 'EXone' DAS effectively reduces both fatigue and fatigability in DMD patients and healthy controls. Despite the methodological shortcomings, this research is one of the first studies investigating the impact of DAS on fatigue and fatigability.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17483107.2024.2388284","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Due to progressive muscle wasting and weakness in patients with Duchenne Muscular Dystrophy (DMD), physical fatigability increases, upper extremity function reduces, which negatively impacts quality of life. Assistive technology such as dynamic arm supports (DAS) may help reduce this fatigability. This study aims to assess whether the novel Yumen 'EXone' DAS can reduce upper extremity fatigue and fatigability in DMD patients and healthy controls (HC), both with and without the DAS. Additionally, longitudinal changes in DMD patients were evaluated.
Methods: Five DMD patients from the Yumen Bionics pioneer program and five HCs participated. Two submaximal tests simulating drinking and reaching were performed for two minutes, each with and without DAS. DMD participants completed these tests twice, at baseline (T0) and after 6-9 months (T1), while HCs completed them once. Physical fatigability was measured by the number of repetitions and changes in surface electromyography (sEMG) amplitude. Subjective fatigue was assessed using the Borg Scale (6-20) Rate of Perceived Exertion (RPE).
Results: DMD participants generally performed more repetitions with the DAS than without. HCs showed similar or increased repetitions with the DAS. Assessing fatigability with sEMG was difficult due to the compensatory mechanisms used for the tests. Subjective fatigue scores on the Borg Scale were lower with the DAS for both DMD patients and HCs.
Conclusion: The Yumen 'EXone' DAS effectively reduces both fatigue and fatigability in DMD patients and healthy controls. Despite the methodological shortcomings, this research is one of the first studies investigating the impact of DAS on fatigue and fatigability.
背景：由于杜兴氏肌肉萎缩症（DMD）患者的肌肉逐渐萎缩和虚弱，身体疲劳度增加，上肢功能降低，对生活质量产生了负面影响。动态手臂支撑（DAS）等辅助技术可帮助减轻这种疲劳感。本研究旨在评估新型玉门 "EXone "DAS 是否能减轻 DMD 患者和健康对照组（HC）的上肢疲劳。此外，还评估了 DMD 患者的纵向变化：五名来自玉门仿生先驱项目的 DMD 患者和五名健康对照组参加了此次研究。在有 DAS 和没有 DAS 的情况下，分别进行了两分钟的模拟喝水和伸手的亚极限测试。DMD 参与者分别在基线（T0）和 6-9 个月后（T1）完成了两次测试，而 HC 参与者只完成了一次。身体疲劳度通过重复次数和表面肌电图 (sEMG) 振幅的变化进行测量。主观疲劳度采用博格量表（6-20）知觉劳累率（RPE）进行评估：结果：使用 DAS 的 DMD 参与者的重复次数普遍高于不使用 DAS 的参与者。使用 DAS 时，HCs 的重复次数与使用 DAS 时相似或有所增加。由于在测试中使用了补偿机制，因此用 sEMG 评估疲劳度比较困难。使用 DAS 时，DMD 患者和 HC 的博格量表主观疲劳评分均较低：结论：玉门 "EXone "DAS 可有效减轻 DMD 患者和健康对照组的疲劳感。尽管存在方法上的不足，但这项研究是首批调查 DAS 对疲劳和易疲劳性影响的研究之一。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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