The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators Pub Date : 2024-09-19 DOI:10.1016/j.prostaglandins.2024.106907

Hawal Lateef Fateh , Dyari H. Ahmed , Maryam Sharifi Najafabadi , Jalal Moludi

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Abstract

This comprehensive systematic review and meta-analysis sought to investigate the impact of chia seed supplementation on obesity indicators and metabolic factors. Through a thorough search of relevant studies up to April 2024, 14 clinical trials involving 835 participants were included in the analysis. The findings revealed a notable decrease in triglyceride levels across both higher and lower doses of chia seeds, with weighted mean differences (WMD) of −8.69 mg/dL and −13.11 mg/dL, respectively. Additionally, a statistically significant reduction in LDL-C levels was observed solely in the higher dosage group, showing a WMD of −4.77 mg/dL. Moreover, although the decrease in systolic blood pressure (-2.78 mmHg) compared to the control group was statistically significant, it was only observed with the higher dosage. These results suggest that chia supplementation may offer beneficial effects on dyslipidemia, hypertension, and body weight, potentially mitigating the risk of cardiovascular disease.

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奇异籽对糖尿病、血压、血脂和肥胖指标的影响：对 14 项随机对照试验的系统回顾和元回归分析。

这项全面的系统综述和荟萃分析旨在研究补充奇异籽对肥胖指标和代谢因素的影响。通过对截至 2024 年 4 月的相关研究进行全面搜索，14 项涉及 835 名参与者的临床试验被纳入分析范围。研究结果显示，较高和较低剂量的奇异籽都能显著降低甘油三酯水平，加权平均差（WMD）分别为-8.69毫克/分升和-13.11毫克/分升。此外，只有高剂量组的低密度脂蛋白胆固醇（LDL-C）水平出现了统计学意义上的显著降低，加权平均差（WMD）为-4.77毫克/分升。此外，虽然与对照组相比，收缩压的降低（-2.78mmHg）具有统计学意义，但这只在高剂量组中观察到。这些结果表明，补充奇异果可能会对血脂异常、高血压和体重产生有益的影响，从而有可能降低心血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.