Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome-A Pilot Study.

IF 3.2 Q2 CLINICAL NEUROLOGY
Leonie Zerweck, Uwe Klose, Annerose Mengel, Tobias Hoheisel, Melinda Eikemeier, Vivien Richter, Natalie Sophie Joos, Ulrike Ernemann, Benjamin Bender, Till-Karsten Hauser
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Abstract

Endothelial dysfunction represents a potential pathomechanism of neurological post-COVID-19 syndrome (PCS). A recent study demonstrated reduced cerebrovascular reactivity (CVR) in patients with PCS. The aim of this pilot study was to prospectively assess CVR in patients with PCS using breath-hold functional MRI (bh-fMRI). Fourteen patients with neurological PCS and leading symptoms of fatigue/memory issues/concentration disorder (PCSfmc), 11 patients with PCS and leading symptoms of myopathy/neuropathy (PCSmn), and 17 healthy controls underwent bh-fMRI. Signal change and time to peak (TTP) were assessed globally and in seven regions of interest and compared between the subgroups using one-way ANCOVA adjusting for age, time since infection, Fazekas score, and sex. No significant differences were observed. In PCS patients, the global CVR exhibited a slight, non-significant tendency to be lower compared to healthy controls (PCSfmc: 0.78 ± 0.11%, PCSmn: 0.84 ± 0.10% and 0.87 ± 0.07%). There was a non-significant trend towards lower global TTP values in the PCS subgroups than in the control group (PCSfmc: 26.41 ± 1.39 s, PCSmn: 26.32 ± 1.36 s versus 29.52 ± 0.93 s). Endothelial dysfunction does not seem to be the sole pathomechanism of neurological symptoms in PCS. Further studies in larger cohorts are required.

通过屏气功能磁共振成像评估神经系统后 COVID-19 综合征患者的脑血管反应性--试点研究
内皮功能障碍是导致神经性后 COVID-19 综合征(PCS)的潜在病理机制。最近的一项研究表明,PCS 患者的脑血管反应性(CVR)降低。本试验性研究旨在利用屏气功能磁共振成像(bh-fMRI)对 PCS 患者的 CVR 进行前瞻性评估。14名患有神经性PCS并伴有疲劳/记忆问题/注意力不集中等主要症状的患者(PCSfmc)、11名患有PCS并伴有肌病/神经病等主要症状的患者(PCSmn)和17名健康对照者接受了bh-fMRI检查。对信号变化和达到峰值的时间(TTP)进行了全面评估,并对七个感兴趣的区域进行了评估,通过单因素方差分析对年龄、感染后时间、法泽卡斯评分和性别进行了调整,比较了不同亚组之间的差异。未观察到明显差异。与健康对照组相比,PCS 患者的总体 CVR 呈轻微的、非显著性的降低趋势(PCSfmc:0.78 ± 0.11%;PCSmn:0.84 ± 0.10% 和 0.87 ± 0.07%)。与对照组相比(PCSfmc:26.41±1.39 秒;PCSmn:26.32±1.36 秒对 29.52±0.93 秒),PCS 亚组的总 TTP 值呈非显著性降低趋势。内皮功能障碍似乎不是 PCS 神经症状的唯一病理机制。还需要在更大的队列中进行进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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