Gut microbiota and renal fibrosis

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-09-21 DOI:10.1016/j.lfs.2024.123072

引用次数: 0

Abstract

Renal fibrosis represents a critical pathological condition in the progression of renal dysfunction, characterized by aberrant accumulation of extracellular matrix (ECM) and structural alterations in renal tissue. Recent research has highlighted the potential significance of gut microbiota and demonstrated their influence on host health and disease mechanisms through the production of bioactive metabolites. This review examines the role of alterations in gut microbial composition and their metabolites in the pathophysiological processes underlying renal fibrosis. It delineates current therapeutic interventions aimed at modulating gut microbiota composition, encompassing dietary modifications, pharmacological approaches, and probiotic supplementation, while evaluating their efficacy in mitigating renal fibrosis. Through a comprehensive analysis of current research findings, this review enhances our understanding of the bidirectional interaction between gut microbiota and renal fibrosis, establishing a theoretical foundation for future research directions and potential clinical applications in this domain.

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肠道微生物群与肾脏纤维化

肾脏纤维化是肾功能障碍进展过程中的一种重要病理状态，其特点是细胞外基质（ECM）的异常积累和肾组织结构的改变。最近的研究强调了肠道微生物群的潜在意义，并证明了它们通过产生生物活性代谢物对宿主健康和疾病机制的影响。本综述探讨了肠道微生物组成及其代谢物的改变在肾脏纤维化的病理生理过程中的作用。它描述了目前旨在调节肠道微生物群组成的治疗干预措施，包括饮食调节、药物治疗和补充益生菌，同时评估了这些措施在减轻肾脏纤维化方面的疗效。通过对当前研究成果的全面分析，本综述加深了我们对肠道微生物群与肾脏纤维化之间双向互动关系的理解，为这一领域未来的研究方向和潜在的临床应用奠定了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.