HIT4HYPOS Continuous Glucose Monitoring Data Analysis: The Effects of High-Intensity Interval Training on Hypoglycemia in People With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.

IF 4.1 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Science and Technology Pub Date : 2024-09-23 DOI:10.1177/19322968241273845

Catriona M Farrell, Giacomo Cappon, Daniel J West, Andrea Facchinetti, Rory J McCrimmon

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Abstract

Aims: To assess the impact of high-intensity interval training (HIIT) on hypoglycemia frequency and duration in people with type 1 diabetes (T1D) with impaired awareness of hypoglycemia (IAH).

Methods: Post hoc analysis of four weeks of continuous glucose monitoring (CGM) data from HIT4HYPOS; a parallel-group study comparing HIIT + CGM versus no exercise + CGM in 18 participants with T1D and IAH.

Results: When compared with those participating individuals not exercising, HIIT did not increase total hypoglycemia frequency, T_Hypo(L1) 1.44 [1.00-2.77]% versus 2.53 [1.46-4.23]%; P = .335, T_Hypo(L2) 0.25 [0.09-0.37]% versus 0.45 [0.20-0.78]%; P = .146, HIIT + CGM versus CGM, respectively, rate (EventPerWeek_Hypo 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week, P = .340) or duration (Duration_Hypo 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; P = .219, HIIT + CGM vs CGM, respectively). There was a reduction in nocturnal hypoglycemia in those who carried out HIIT, T_Hypo_(L1) 0.50 [0.13-0.97]% versus 2.45 [0.77-4.74]%; P = .076; T_Hypo_(L2) 0.00 [0.00-0.03]% versus 0.49 [0.13-0.74]%; P = .006, HIIT + CGM versus CGM, respectively.

Conclusions/interpretation: Based on CGM data collected from a real-world study of four weeks of HIIT versus no exercise in individuals with T1D and IAH, we conclude that HIIT does not increase hypoglycemia, and in fact reduces exposure to nocturnal hypoglycemia.

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HIT4HYPOS 连续血糖监测数据分析：高强度间歇训练对 1 型糖尿病患者和低血糖意识受损者低血糖的影响。

目的：评估高强度间歇训练（HIIT）对伴有低血糖意识受损（IAH）的1型糖尿病（T1D）患者低血糖发生频率和持续时间的影响：方法：对 HIT4HYPOS 四周连续血糖监测（CGM）数据进行事后分析；这是一项平行分组研究，比较了 HIIT + CGM 与不运动 + CGM 对 18 名患有 T1D 和 IAH 的参与者的影响：结果：与不运动的参与者相比，HIIT没有增加低血糖的总频率，THypo(L1) 1.44 [1.00-2.77]% 对 2.53 [1.46-4.23]%; P = .335, THypo(L2) 0.25 [0.09-0.37]% 对 0.45 [0.20-0.78]%; P = .在这两项研究中，患者的夜间睡眠时间（HIIT + CGM vs CGM，分别为 0.25 [0.09-0.37]% 对 0.45 [0.20-0.78]%; P = .146）、发生率（EventPerWeekHypo 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week，P = .340）或持续时间（DurationHypo 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; P = .219，HIIT + CGM vs CGM，分别为 0.25 [0.09-0.37]% 对 0.45 [0.20-0.78]%; P = .HIIT + CGM 与 CGM 相比，进行 HIIT 的患者夜间低血糖发生率有所下降，THypo(L1) 0.50 [0.13-0.97]% 与 2.45 [0.77-4.74]% 相比；P = .076；THypo(L2) 0.00 [0.00-0.03]% 与 0.49 [0.13-0.74]% 相比；P = .006：根据对 T1D 和 IAH 患者进行的一项为期四周的 HIIT 与不运动对比的真实世界研究中收集的 CGM 数据，我们得出结论：HIIT 不会增加低血糖，事实上还能减少夜间低血糖的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Science and Technology Medicine-Internal Medicine

CiteScore

7.50

自引率

12.00%

发文量

148

期刊介绍： The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.