Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review).

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI:10.3892/ijmm.2024.5429

Qian Liu, Jiajia Li, Xin Li, Li Zhang, Shun Yao, Yongfeng Wang, Biguang Tuo, Hai Jin

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引用次数: 0

Abstract

Liver fibrosis is a pathophysiologic manifestation of chronic liver disease and a precursor to cirrhosis and hepatocellular carcinoma. Glycolysis provides intermediate metabolites as well as energy support for cell proliferation and phenotypic transformation in liver fibers. 6‑Phosphofructo‑2‑kinase/fructose‑2,6‑bisphosphatase 3 (PFKFB3) is a key activator of glycolysis and plays an important role in the process of glycolysis. The role of PFKFB3‑mediated glycolysis in myocardial fibrosis, renal fibrosis and pulmonary fibrosis has been demonstrated, and the role of PFKFB3 in the activation of hepatic stellate cells by aerobic glycolysis has been proven by relevant experiments. The present study reviews the research progress on the role and mechanism of action of PFKFB3‑mediated glycolysis in the progression of hepatic fibrosis to discuss the role of PFKFB3‑mediated glycolysis in hepatic fibrosis and to provide new ideas for research on PFKFB3 as a target for the treatment of hepatic fibrosis.

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对 PFKFB3 介导的糖酵解在肝纤维化中的作用和作用机制的认识取得进展（综述）。

肝纤维化是慢性肝病的一种病理生理表现，也是肝硬化和肝细胞癌的前兆。糖酵解为肝纤维中的细胞增殖和表型转化提供中间代谢产物和能量支持。6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 3（PFKFB3）是糖酵解的关键激活剂，在糖酵解过程中发挥着重要作用。PFKFB3 介导的糖酵解在心肌纤维化、肾脏纤维化和肺纤维化中的作用已被证实，PFKFB3 在有氧糖酵解激活肝星状细胞中的作用也已被相关实验证实。本研究回顾了PFKFB3介导的糖酵解在肝纤维化进展中的作用及作用机制的研究进展，探讨了PFKFB3介导的糖酵解在肝纤维化中的作用，为PFKFB3作为肝纤维化治疗靶点的研究提供了新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.