Monoclonal antibodies against pediatric ulcerative colitis: a review of clinical progress.

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Expert Opinion on Biological Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI:10.1080/14712598.2024.2404076
Debora Curci, Marianna Lucafò, Giuliana Decorti, Gabriele Stocco
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引用次数: 0

Abstract

Introduction: In children, ulcerative colitis (UC) is often more severe and extensive than in adults and hospitalization for acute exacerbations occurs in around a quarter of subjects. There is a need for effective drugs, which could avoid or reduce the use of corticosteroids which, especially in children, are burdened by a number of severe side effects. The introduction in therapy of monoclonal antibodies has completely changed the therapeutic scenario and the prognosis of the disease.

Areas covered: In this review, the use of the monoclonal antibodies directed against tumor necrosis factor (TNF)α or other inflammatory targets for the treatment of pediatric UC will be discussed. A search of the literature was done using the keywords 'pediatric,' 'ulcerative colitis,' 'inflammatory bowel disease,' 'monoclonal antibodies;' 'infliximab,' 'adalimumab,' 'golimumab,' vedolizumab," 'ustekinumab' and 'risankizumab.'

Expert opinion: The use of monoclonal antibodies has greatly increased in recent years in pediatric UC, both in patients who did not respond to conventional therapies, and, more often, as initial therapy. Thanks to therapeutic drug monitoring and to the availability of biologics with different targets, therapy has become more targeted and personalized, with a significant improvement in response, in quality of life, and with a good safety profile.

针对小儿溃疡性结肠炎的单克隆抗体:临床进展回顾。
简介儿童溃疡性结肠炎(UC)通常比成人更为严重和广泛,约四分之一的患者会因急性加重而住院治疗。我们需要有效的药物,以避免或减少皮质类固醇的使用,尤其是对儿童而言,皮质类固醇有许多严重的副作用。单克隆抗体疗法的引入彻底改变了该病的治疗方案和预后:本综述将讨论针对肿瘤坏死因子(TNF)α或其他炎症靶点的单克隆抗体用于治疗小儿 UC 的情况。我们使用'儿科'、'溃疡性结肠炎'、'炎症性肠病'、'单克隆抗体'、'英夫利昔单抗'、'阿达木单抗'、'戈利木单抗'、'维多珠单抗'、'乌司他单抗'和'利抗珠单抗'等关键词对文献进行了检索:近年来,单克隆抗体在小儿UC中的使用大幅增加,既用于对传统疗法无效的患者,也更多地作为初始疗法。得益于治疗药物监测和具有不同靶点的生物制剂的出现,治疗变得更具针对性和个性化,治疗效果和生活质量显著提高,而且安全性良好。
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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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