The role of microRNAs in pregnancies complicated by maternal diabetes.

IF 6.7 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Manon D Owen, Margeurite G Kennedy, Rachel C Quilang, Eleanor M Scott, Karen Forbes
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引用次数: 0

Abstract

With the global prevalence of diabetes increasing, more people of reproductive age are experiencing hyperglycaemic pregnancies. Maternal Type 1 (T1DM) or Type 2 (T2DM) diabetes mellitus, and gestational diabetes mellitus (GDM) are associated with maternal cardiovascular and metabolic complications. Pregnancies complicated by maternal diabetes also increase the risk of short- and long-term health complications for the offspring, including altered fetal growth and the onset of T2DM and cardiometabolic diseases throughout life. Despite advanced methods for improving maternal glucose control, the prevalence of adverse maternal and offspring outcomes associated with maternal diabetes remains high. The placenta is a key organ at the maternal-fetal interface that regulates fetal growth and development. In pregnancies complicated by maternal diabetes, altered placental development and function has been linked to adverse outcomes in both mother and fetus. Emerging evidence suggests that microRNAs (miRNAs) are key molecules involved in mediating these changes. In this review, we describe the role of miRNAs in normal pregnancy and discuss how miRNA dysregulation in the placenta and maternal circulation is associated with suboptimal placental development and pregnancy outcomes in individuals with maternal diabetes. We also discuss evidence demonstrating that miRNA dysregulation may affect the long-term health of mothers and their offspring. As such, miRNAs are potential candidates as biomarkers and therapeutic targets in diabetic pregnancies at risk of adverse outcomes.

微RNA在妊娠合并糖尿病中的作用。
随着全球糖尿病患病率的上升,越来越多的育龄妇女经历了高血糖妊娠。母体 1 型糖尿病(T1DM)或 2 型糖尿病(T2DM)以及妊娠糖尿病(GDM)与母体心血管和代谢并发症有关。妊娠并发糖尿病还会增加后代短期和长期健康并发症的风险,包括胎儿生长发育改变、T2DM 和终生心血管代谢疾病。尽管采用了先进的方法来改善孕产妇的血糖控制,但与孕产妇糖尿病相关的孕产妇和后代不良后果的发生率仍然很高。胎盘是母胎界面上的一个关键器官,负责调节胎儿的生长发育。在母体糖尿病并发妊娠中,胎盘发育和功能的改变与母亲和胎儿的不良结局有关。新的证据表明,microRNA(miRNA)是介导这些变化的关键分子。在这篇综述中,我们描述了 miRNA 在正常妊娠中的作用,并讨论了胎盘和母体循环中的 miRNA 失调如何与母体糖尿病患者的胎盘发育不良和妊娠结局相关。我们还讨论了 miRNA 失调可能影响母亲及其后代长期健康的证据。因此,miRNAs 有可能成为有不良后果风险的糖尿病孕妇的生物标记物和治疗目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical science
Clinical science 医学-医学:研究与实验
CiteScore
11.40
自引率
0.00%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively: Cardiovascular system Cerebrovascular system Gastrointestinal tract and liver Genomic medicine Infection and immunity Inflammation Oncology Metabolism Endocrinology and nutrition Nephrology Circulation Respiratory system Vascular biology Molecular pathology.
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