Abnormal serum Magnesium Level is Associated with the Coagulopathy in Traumatic Brain Injury Patients.

IF 2.3 4区 医学 Q2 HEMATOLOGY
Ruoran Wang, Jianguo Xu, Min He
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Abstract

Background: Coagulopathy is associated with poor prognosis of traumatic brain injury (TBI) patients. This study is performed to explore the association between serum magnesium level and the risk of coagulopathy in TBI.

Methods: TBI patients from the Medical Information Mart for Intensive Care-III database were included for this study. Logistic regression analysis was performed to explore risk factors and develop a predictive model for coagulopathy in TBI. The restricted cubic spline (RCS) was utilized to analyze the association between serum magnesium level and the development of coagulopathy. Receiver operating characteristic curve was drawn to evaluate the performance of the predictive model for coagulopathy.

Results: The incidence of coagulopathy in TBI was 32.6%. The RCS indicated the association between magnesium and coagulopathy was U-shaped. Multivariate logistic regression confirmed age, coronary heart disease, cerebral vascular disease, chronic liver disease, GCS, ISS, epidural hematoma, hemoglobin, shock index and magnesium level were independently associated with the coagulopathy in TBI. Compared with patients of magnesium level between 1.7 and 2.3 mg/dL, those with magnesium level below 1.7 mg/dL or above 2.2 mg/dL had a higher risk of coagulopathy.

Conclusion: Both hypermagnesemia and hypomagnesemia are associated with higher risk of coagulopathy in TBI patients. Physicians should pay more attention on preventing coagulopathy in TBI patients with hypomagnesemia or hypermagnesemia.

血清镁水平异常与脑外伤患者的凝血功能障碍有关
背景:凝血病与创伤性脑损伤(TBI)患者的不良预后有关。本研究旨在探讨血清镁水平与创伤性脑损伤患者发生凝血病的风险之间的关系:本研究纳入了重症监护医学信息中心-III数据库中的创伤性脑损伤患者。方法:本研究纳入了重症监护医学信息市场-III数据库中的创伤性脑损伤患者,并进行了逻辑回归分析,以探究创伤性脑损伤患者发生凝血病的风险因素并建立预测模型。利用受限立方样条曲线(RCS)分析血清镁水平与凝血病发生之间的关联。绘制了接收者操作特征曲线,以评估凝血病预测模型的性能:结果:创伤性脑损伤患者的凝血病发生率为 32.6%。RCS显示镁与凝血病之间的关系呈U形。多变量逻辑回归证实年龄、冠心病、脑血管疾病、慢性肝病、GCS、ISS、硬膜外血肿、血红蛋白、休克指数和镁水平与创伤性脑损伤患者的凝血病独立相关。与血镁水平在 1.7 至 2.3 毫克/分升之间的患者相比,血镁水平低于 1.7 毫克/分升或高于 2.2 毫克/分升的患者发生凝血病的风险更高:结论:高镁血症和低镁血症都与创伤性脑损伤患者发生凝血病的高风险有关。结论:高镁血症和低镁血症与创伤性脑损伤患者发生凝血病的风险较高有关,医生应更加重视预防创伤性脑损伤患者发生凝血病。
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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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