Prognostic and immunological roles of RSPO1 in pan-cancer and its correlation with LUAD proliferation and metastasis.

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/DLVS6991

Xinqi Lou, Yuanyuan Wang, Yanjun Deng, Jiao Yang, Duo Xu, Mingdeng Wang, Yuansheng Lin

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Abstract

Aberrant RSPO1 expression is implicated in tumor progression across various cancers and correlates with anti-cancer immune cell characteristics. However, the specific role of R-spondin 1 (RSPO1) in lung adenocarcinoma (LUAD) remains unclear. In this study, we utilized data from The Cancer Genome Atlas (TCGA) to assess RSPO1 expression across 33 tumor types. Kaplan-Meier (K-M) analysis revealed the prognostic significance of RSPO1 in various cancers. Using statistical software R, we examined RSPO1's associations with immune cell infiltration, methylation, mutation, and competing endogenous RNA (ceRNA) networks. Exploration via the Tumor Immune Single Cell Hub (TISCH) database uncovered RSPO1's link to the tumor microenvironment (TME) and identified potential small molecule drug targets. We further investigated RSPO1's impact on LUAD cell proliferation, metastasis, and the Wnt pathway in vitro. Our findings highlight RSPO1's role in cancer progression and suggest its potential as both a prognostic marker and therapeutic target in LUAD, implicating the modulation of the Wnt pathway.

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RSPO1 在泛癌症中的预后和免疫学作用及其与 LUAD 增殖和转移的相关性。

RSPO1 的异常表达与各种癌症的肿瘤进展有关，并与抗癌免疫细胞的特性相关。然而，R-spondin 1（RSPO1）在肺腺癌（LUAD）中的具体作用仍不清楚。在这项研究中，我们利用癌症基因组图谱（TCGA）的数据评估了 33 种肿瘤类型中 RSPO1 的表达情况。Kaplan-Meier（K-M）分析揭示了RSPO1在各种癌症中的预后意义。我们使用 R 统计软件研究了 RSPO1 与免疫细胞浸润、甲基化、突变和竞争性内源性 RNA（ceRNA）网络的关联。通过肿瘤免疫单细胞中心（TISCH）数据库的探索发现了 RSPO1 与肿瘤微环境（TME）的联系，并确定了潜在的小分子药物靶点。我们进一步研究了 RSPO1 对 LUAD 细胞增殖、转移和体外 Wnt 通路的影响。我们的研究结果突显了 RSPO1 在癌症进展中的作用，并表明它有可能成为 LUAD 的预后标志物和治疗靶点，这与 Wnt 通路的调节有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.