Transcriptomic analysis-based study on the response mechanism of juvenile golden cuttlefish (Sepia esculenta) to benzo[a]pyrene exposure

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Fei Han, Xiaodong Zheng
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Abstract

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon from incomplete combustion, builds up in coastal regions through river runoff, atmospheric deposition, and coastal activities. BaP's lipophilicity and stability lead to persistent environmental impacts due to its resistance to degradation. The economically valuable golden cuttlefish, Sepia esculenta, often spawns and hatches in shallow waters, making it prone to BaP exposure. This study employs transcriptomic analysis to initially investigate juvenile golden cuttlefish's response to BaP. The results indicate that BaP exposure significantly affects various physiological and molecular functions of the juveniles, particularly affecting pathways related to immune and inflammatory responses, metabolic regulation, and nervous system functions. Functional enrichment and PPI network analyses identified key genes such as HSGALT-like, ASAH1-like, and GTL-like in the BaP response. These genes exhibited a suppressive trend during short-term exposure, indicating that BaP exposure may influence lipid metabolism, energy conversion, and digestive functions at the genetic level, which could further disrupt the overall physiological state and developmental processes of juvenile golden cuttlefish. The study offers novel insights into BaP's effects on juvenile golden cuttlefish and marine life, aiding marine ecosystem and biodiversity conservation.

Abstract Image

基于转录组分析的金乌贼幼体对苯并[a]芘暴露的反应机制研究
苯并[a]芘(BaP)是一种不完全燃烧产生的多环芳烃,通过河流径流、大气沉降和沿海活动在沿海地区积累。BaP 具有亲脂性和稳定性,不易降解,因此会对环境造成持续影响。具有经济价值的金乌贼(Sepia esculenta)经常在浅水中产卵和孵化,因此很容易接触到 BaP。本研究采用转录组分析法初步研究了金乌贼幼鱼对苯并[a]芘的反应。结果表明,暴露于BaP会显著影响幼体的各种生理和分子功能,特别是影响与免疫和炎症反应、代谢调节和神经系统功能相关的通路。功能富集和 PPI 网络分析确定了 BaP 反应中的关键基因,如 HSGALT-like、ASAH1-like 和 GTL-like。这些基因在短期暴露过程中表现出抑制趋势,表明BaP暴露可能在基因水平上影响脂质代谢、能量转换和消化功能,从而进一步破坏金乌贼幼鱼的整体生理状态和发育过程。该研究为了解 BaP 对幼体金乌贼和海洋生物的影响提供了新的视角,有助于海洋生态系统和生物多样性的保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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