Can tissue-specific PD-1/PD-L1 targeting combined with other immune checkpoint blockades enhance immune clearance?

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-19 DOI:10.1016/j.mehy.2024.111491

Sadia Ahmad , Amna Rehman , Ali Afzal , Muhammad Babar Khawar

引用次数: 0

Abstract

Age-related disorders are exacerbated by senescent cells (SnCs) due to their secretion of proinflammatory molecules, yet current therapeutic strategies have limited success in preclinical settings and clinical trials. A novel approach is needed to enhance SnCs clearance by targeting immune checkpoints, particularly the PD-1/PD-L1 axis, combined with tissue-specific delivery of therapeutic agents. This strategy is critical in reducing the chronic inflammation and improving tissue health in aging populations. However, challenges such as immune evasion by SnCs and potential autoimmune responses must be addressed. The aim of this manuscript is to propose a combined approach to improve the efficacy of senolytic therapy.

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组织特异性PD-1/PD-L1靶向与其他免疫检查点阻断剂联合使用能否提高免疫清除率？

衰老细胞（SnCs）会分泌促炎分子，从而加剧与年龄有关的疾病，但目前的治疗策略在临床前和临床试验中收效甚微。我们需要一种新的方法，通过靶向免疫检查点（尤其是 PD-1/PD-L1 轴），结合组织特异性治疗药物的递送，来加强 SnCs 的清除。这一策略对于减少慢性炎症和改善老龄人群的组织健康至关重要。然而，必须应对 SnCs 的免疫逃避和潜在的自身免疫反应等挑战。本手稿旨在提出一种综合方法，以提高溶老疗法的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.