Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory

IF 3.7 2区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

ACS Synthetic Biology Pub Date : 2024-09-20 DOI:10.1021/acssynbio.4c0027610.1021/acssynbio.4c00276

Karmella A. Haynes*, Lauren B. Andrews, Chase L. Beisel, James Chappell, Christian E. Cuba Samaniego, John E. Dueber, Mary J. Dunlop, Elisa Franco, Julius B. Lucks, Vincent Noireaux, David F. Savage, Pamela A. Silver, Michael Smanski and Eric Young,

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Abstract

The Cold Spring Harbor Laboratory (CSHL) Summer Course on Synthetic Biology, established in 2013, has emerged as a premier platform for immersive education and research in this dynamic field. Rooted in CSHL’s rich legacy of biological discovery, the course offers a comprehensive exploration of synthetic biology’s fundamentals and applications. Led by a consortium of faculty from diverse institutions, the course structure seamlessly integrates practical laboratory sessions, exploratory research rotations, and enriching seminars by leaders in the field. Over the years, the curriculum has evolved to cover essential topics such as cell-free transcription–translation, DNA construction, computational modeling of gene circuits, engineered gene regulation, and CRISPR technologies. In this review, we describe the history, development, and structure of the course, and discuss how elements of the course might inform the development of other short courses in synthetic biology. We also demonstrate the course’s impact beyond the lab with a summary of alumni contributions to research, education, and entrepreneurship. Through these efforts, the CSHL Summer Course on Synthetic Biology remains at the forefront of shaping the next generation of synthetic biologists.

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冷泉港实验室合成生物学暑期班十年回顾

冷泉港实验室（CSHL）合成生物学暑期课程成立于 2013 年，现已成为这一充满活力的领域开展沉浸式教育和研究的首要平台。该课程植根于 CSHL 丰富的生物发现传统，全面探索合成生物学的基础知识和应用。该课程由来自不同机构的教师组成的联合体领导，课程结构完美地整合了实用的实验室课程、探索性的研究轮换以及由该领域领导者主持的内容丰富的研讨会。多年来，该课程不断发展，涵盖了无细胞转录-翻译、DNA 构建、基因回路计算建模、工程基因调控和 CRISPR 技术等基本主题。在这篇综述中，我们介绍了该课程的历史、发展和结构，并讨论了该课程的要素如何为其他合成生物学短期课程的发展提供参考。我们还通过总结校友对研究、教育和创业的贡献，展示了该课程在实验室之外的影响。通过这些努力，CSHL 合成生物学暑期课程在培养下一代合成生物学家方面始终处于领先地位。

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来源期刊

ACS Synthetic Biology 生物-

CiteScore

8.00

自引率

10.60%

发文量

380

审稿时长

6-12 weeks

期刊介绍： The journal is particularly interested in studies on the design and synthesis of new genetic circuits and gene products; computational methods in the design of systems; and integrative applied approaches to understanding disease and metabolism. Topics may include, but are not limited to: Design and optimization of genetic systems Genetic circuit design and their principles for their organization into programs Computational methods to aid the design of genetic systems Experimental methods to quantify genetic parts, circuits, and metabolic fluxes Genetic parts libraries: their creation, analysis, and ontological representation Protein engineering including computational design Metabolic engineering and cellular manufacturing, including biomass conversion Natural product access, engineering, and production Creative and innovative applications of cellular programming Medical applications, tissue engineering, and the programming of therapeutic cells Minimal cell design and construction Genomics and genome replacement strategies Viral engineering Automated and robotic assembly platforms for synthetic biology DNA synthesis methodologies Metagenomics and synthetic metagenomic analysis Bioinformatics applied to gene discovery, chemoinformatics, and pathway construction Gene optimization Methods for genome-scale measurements of transcription and metabolomics Systems biology and methods to integrate multiple data sources in vitro and cell-free synthetic biology and molecular programming Nucleic acid engineering.