Decoding the diabetic bone paradox: How AGEs sabotage skeletal integrity

IF 11.7 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2024-09-17 DOI:10.1016/j.xcrm.2024.101693

Juan Wang, Wenguo Cui

引用次数: 0

Abstract

Diabetes patients often suffer from fractures despite normal or high bone mineral density, a phenomenon known as the diabetic bone paradox. Gao et al.¹ identify AGEs as disrupting bone quality and compromising skeletal integrity in diabetic bone disease.

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解密糖尿病骨骼悖论：AGE 如何破坏骨骼完整性

糖尿病患者尽管骨矿密度正常或较高，但仍经常发生骨折，这种现象被称为糖尿病骨悖论。Gao 等人1 认为 AGEs 会破坏骨质，损害糖尿病骨病患者骨骼的完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.