{"title":"Iodine-Promoted Cascade Redox Cyclization to Access 2-Arylbenzothiazoles Using Elemental Sulfur","authors":"Yakkanti Chiranjeevi, Sujeet Gaware, Rana Chatterjee, Jayshree Solanke, Rapolu Venkateshwarlu, L. Vaikunta Rao, Gorle Simhachalam, Rambabu Dandela","doi":"10.1002/jhet.4902","DOIUrl":null,"url":null,"abstract":"A straightforward and efficient method has been developed to access a variety of benzothiazole derivatives via cascade reductive annulation. Iodine mediated, one-pot three-component reaction of <i>o</i>-chloronitroarenes, aryl aldehydes, and elemental sulfur effectively produce benzothiazoles. Moreover, the metal-free strategy allows the facile synthesis of diverse 2-substituted benzothiazoles through multiple carbon–heteroatom bonds in good yields. The present protocol features a greener approach, readily accessible reagents, broad substrate scope, high product yields, and operational simplicity.","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/jhet.4902","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A straightforward and efficient method has been developed to access a variety of benzothiazole derivatives via cascade reductive annulation. Iodine mediated, one-pot three-component reaction of o-chloronitroarenes, aryl aldehydes, and elemental sulfur effectively produce benzothiazoles. Moreover, the metal-free strategy allows the facile synthesis of diverse 2-substituted benzothiazoles through multiple carbon–heteroatom bonds in good yields. The present protocol features a greener approach, readily accessible reagents, broad substrate scope, high product yields, and operational simplicity.
期刊介绍:
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.