o-CLEAN: a novel multi-stage algorithm for the ocular artifacts' correction from EEG data in out-of-the-lab applications.

Abstract

In the context of Electroencephalographic (EEG) signal processing, artifacts generated by ocular movements, such as blinks, are significant confounding factors. These artifacts overwhelm informative EEG features and may occur too frequently to simply remove affected epochs without losing valuable data. Correcting these artifacts remains a challenge, particularly in out-of-lab and online applications using wearable EEG systems (i.e. with low number of EEG channels, without any additional channels to track EOG). OBJECTIVE the main objective of the present work consisted in validating a novel ocular blinks artefacts correction method, named o-CLEAN (multi-stage OCuLar artEfActs deNoising algorithm), suitable for online processing with minimal EEG channels. APPROACH the research was conducted considering one EEG dataset collected in highly controlled environment, and a second one collected in real environment. The analysis was performed by comparing the o-CLEAN method with previously validated state-of-art techniques, and by evaluating its performance along two dimensions: a) the ocular artefacts correction performance (IN-Blink), and b) the EEG signal preservation when the method was applied without any ocular artefacts occurrence (OUT-Blink). MAIN RESULTS results highlighted that i) o-CLEAN algorithm resulted to be, at least, significantly reliable as the most validated approaches identified in scientific literature in terms of ocular blink artifacts correction, ii) o-CLEAN showed the best performances in terms of EEG signal preservation especially with a low number of EEG channels. SIGNIFICANCE the testing and validation of the o-CLEAN addresses a relevant open issue in bioengineering EEG processing, especially within out-of-the-lab application. In fact, the method offers an effective solution for correcting ocular artifacts in EEG signals with a low number of available channels, for online processing, and without any specific template of the EOG. It was demonstrated to be particularly effective for EEG data gathered in real environments using wearable systems, a rapidly expanding area within applied neuroscience.