Contribution of T-type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin-treated mice of both sexes

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2024-09-19 DOI:10.1111/bph.17337

Flavia T. T. Antunes, Maria A. Gandini, Vinicius M. Gadotti, Nara Lins Meira Quintão, José Roberto Santin, Ivana A. Souza, Laurence S. David, Terrance P. Snutch, Michael Hildebrand, Gerald W. Zamponi

引用次数: 0

Abstract

The chemotherapy agent oxaliplatin can give rise to oxaliplatin-induced peripheral neuropathy (OIPN). Here, we investigated whether T-type calcium channels (Ca_v3) contribute to OIPN.

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T型钙通道同工酶对新小鼠和奥沙利铂处理过的雌雄小鼠的冷敏感性和机械敏感性的影响

化疗药物奥沙利铂可引起奥沙利铂诱导的周围神经病变（OIPN）。在此，我们研究了 T 型钙通道（Cav3）是否对 OIPN 起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.