Vortioxetine reduces the development of pain-related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down-regulation

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2024-09-19 DOI:10.1111/bph.17342

Maja Tomić, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Jelena Kotur-Stevuljević, Uroš Pecikoza, David Pavićević, Ana Micov, Danijela Milenković, Aleksandar Jovanović, Radica Stepanović-Petrović

引用次数: 0

Abstract

Vortioxetine, a multimodal-acting antidepressant, has recently shown analgesic properties. We aimed to investigate its prophylactic effect in the osteoarthritis (OA) model and gain insights into the underlying molecular mechanisms. Duloxetine was studied as a reference.

Abstract Image

查看原文本刊更多论文

伏替西汀可减少大鼠膝关节骨关节炎模型中与疼痛相关行为的发展：神经生长因子（NGF）下调的参与作用

伏替西汀是一种多模式作用的抗抑郁药，最近显示出镇痛特性。我们旨在研究它在骨关节炎（OA）模型中的预防效果，并深入了解其潜在的分子机制。研究以度洛西汀为参照物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.