The phytochemical plumbagin: mechanism behind its “pleiotropic” nature and potential as an anticancer treatment

IF 4.8 2区 医学 Q1 TOXICOLOGY
Shikshya Swarupa Panda, Bijesh Kumar Biswal
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引用次数: 0

Abstract

Chemotherapeutics are most often used to treat cancer, but side effects, drug resistance, and toxicity often compromise their effectiveness. In contrast, phytocompound plumbagin possesses a distinct pleiotropic nature, targeting multiple signaling pathways, such as ROS generation, cell death, cellular proliferation, metastasis, and drug resistance, and is shown to enhance the efficacy of chemotherapeutic drugs. Plumbagin has been shown to act synergistically with various chemotherapeutic drugs and enhance their efficacy in drug-resistant cancers. The pleiotropic nature is believed to be due to plumbagin's unique structure, which contains a naphthoquinone ring and a hydroxyl group responsible for plumbagin's various biological responses. Despite limitations such as restricted bioavailability and delivery, recent developments aim to address these challenges and harness the potential of plumbagin as an anticancer therapeutics. This review delves into the structural aspect of the plumbagin molecule contributing to its pleiotropic nature, explores the diverse mechanism that it targets, and discusses emerging strategies to overcome its limitations.

Abstract Image

植物化学物质 plumbagin:其 "多效性 "背后的机制及其作为抗癌疗法的潜力
化疗药物最常用于治疗癌症,但副作用、耐药性和毒性往往会影响其疗效。相比之下,植物化合物 Plumbagin 具有明显的多效性,可针对多种信号通路,如 ROS 生成、细胞死亡、细胞增殖、转移和耐药性,并能增强化疗药物的疗效。研究表明,Plumbagin 能与各种化疗药物协同作用,增强它们对耐药性癌症的疗效。这种多效性被认为是由于 Plumbagin 的独特结构造成的,该结构包含一个萘醌环和一个羟基,羟基负责 Plumbagin 的各种生物反应。尽管存在生物利用度和给药方式受限等局限性,但最近的研究进展旨在应对这些挑战,并利用刺五加苷作为抗癌疗法的潜力。本综述深入探讨了造成 plumbagin 多效应性质的 plumbagin 分子结构方面的问题,探讨了 plumbagin 针对的各种机制,并讨论了克服其局限性的新策略。
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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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