Metabolic regulation in normal and leukemic stem cells

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-09-20 DOI:10.1016/j.tips.2024.08.004

Cheuk-Him Man, Changzheng Li, Xi Xu, Meng Zhao

引用次数: 0

Abstract

Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) are crucial for ensuring hematopoietic homeostasis and driving leukemia progression, respectively. Recent research has revealed that metabolic adaptations significantly regulate the function and survival of these stem cells. In this review, we provide an overview of how metabolic pathways regulate oxidative and proteostatic stresses in HSCs during homeostasis and aging. Furthermore, we highlight targetable metabolic pathways and explore their interactions with epigenetics and the microenvironment in addressing the chemoresistance and immune evasion capacities of LSCs. The metabolic differences between HSCs and LSCs have profound implications for therapeutic strategies.

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正常干细胞和白血病干细胞的代谢调节

造血干细胞（HSCs）和白血病干细胞（LSCs）分别是确保造血稳态和推动白血病进展的关键。最近的研究发现，代谢适应性可显著调节这些干细胞的功能和存活。在这篇综述中，我们概述了造血干细胞在平衡和衰老过程中，代谢途径是如何调节氧化和蛋白应激的。此外，我们还强调了可靶向的代谢途径，并探讨了它们与表观遗传学和微环境的相互作用，以解决造血干细胞的化疗抗性和免疫逃避能力问题。造血干细胞和造血干细胞之间的代谢差异对治疗策略有着深远的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.