Identification, Synthesis, and Characterization of Process Related Impurities in the Synthesis of Boc-L-Lys(Boc)-OSu

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-09-12 DOI:10.1002/jhet.4884

Amit H. Pakhurde, D. V. P. Kishore, Sandeep A. Kotharkar

引用次数: 0

Abstract

Protected lysine esters (Boc-L-Lys(Boc)-OSu) an intermediate of high repute in the peptide synthesis and diverse chemical synthetic applications, was the subject of synthetic process development studies, unveiling process-related impurities. These impurities were synthesized, characterized, and identified by different analytical tools, with their retention times verified by HPLC co-injection with commercial products. Detailed discussions ensued on the potential formation pathways and synthetic strategies of these process-related impurities.

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Boc-L-Lys(Boc)-OSu 合成过程中相关杂质的鉴定、合成和表征

保护赖氨酸酯（Boc-L-Lys(Boc)-OSu）是一种在多肽合成和多种化学合成应用中享有盛誉的中间体，是合成工艺开发研究的主题，揭示了与工艺相关的杂质。我们使用不同的分析工具对这些杂质进行了合成、表征和鉴定，并通过 HPLC 与商业产品共同进样验证了它们的保留时间。随后还详细讨论了这些工艺相关杂质的潜在形成途径和合成策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.