Epistle

Neelam Gupta
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Abstract

While working in a neonatal intensive care setting, I often come across a heavy burden of infections and frequent use of antibiotics. Although there is established guidance for how common antibiotics such as aminoglycosides should be prescribed, administered and monitored, challenges remain about how to facilitate intravenous access for drug delivery in newborns. The actual administration of antibiotics in neonatal and paediatric patients is often more complex than it seems. The delivery kinetics of medications especially for drugs with narrow therapeutic window like aminoglycosides are not well studied. This leads to difficulties in accurately determining the pharmacodynamic and pharmacokinetic drug relationships. In our medicine update section, Abigail Manning and Anna Burgess presents a concise literature review which compares methods of administration of aminoglycosides using intravenous injection vs intravenous infusion in the paediatric setting …
书信
在新生儿重症监护室工作时,我经常会遇到感染负担沉重、抗生素使用频繁的情况。虽然对于氨基糖苷类等常用抗生素的处方、给药和监测都有明确的指导,但如何方便新生儿静脉给药仍然是个难题。新生儿和儿科患者实际使用抗生素的过程往往比想象中复杂。对药物的给药动力学,尤其是对氨基糖苷类等治疗窗口较窄的药物的给药动力学还没有很好的研究。这导致难以准确确定药物的药效学和药代动力学关系。阿比盖尔-曼宁(Abigail Manning)和安娜-伯吉斯(Anna Burgess)在我们的 "药物更新 "栏目中发表了一篇简明扼要的文献综述,对儿科环境中氨基糖苷类药物的静脉注射和静脉输注给药方法进行了比较 ...
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