The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family

IF 4.6 1区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Yongzan Wei, Yi Wang, Fuchu Hu, Wei Wang, Changbin Wei, Bingqiang Xu, Liqin Liu, Huayang Li, Can Wang, Hongna Zhang, Zhenchang Liang, Jianghui Xie
{"title":"The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family","authors":"Yongzan Wei, Yi Wang, Fuchu Hu, Wei Wang, Changbin Wei, Bingqiang Xu, Liqin Liu, Huayang Li, Can Wang, Hongna Zhang, Zhenchang Liang, Jianghui Xie","doi":"10.1016/j.jia.2024.07.043","DOIUrl":null,"url":null,"abstract":"Wampee () is an important evergreen fruit tree native to southern China that has a long history of use for medicinal purposes. Here, a chromosome-level genome of was constructed with a genome size of 282.9 Mb and scaffold N50 of 30.75 Mb. The assembled genome contains 48.70% repetitive elements and 24,381 protein-coding genes. Comparative genomic analysis showed that diverged from Aurantioideae 15.91–24.95 million years ago. Additionally, some expansive and specific gene families related to methyltransferase activity and -adenosylmethionine-dependent methyltransferase activity were also identified. Further analysis indicated that -methyltransferase (NMT) is mainly involved in alkaloid biosynthesis and -methyltransferase (OMT) participates in the regulation of coumarin accumulation in wampee. This suggested that wampee's richness in alkaloids and coumarins might be due to the gene expansions of NMT and OMT. The tandem repeat event was one of the major reasons for the NMT expansion. Hence, the reference genome of will facilitate the identification of some useful medicinal compounds from wampee resources and reveal their biosynthetic pathways.","PeriodicalId":16305,"journal":{"name":"Journal of Integrative Agriculture","volume":"99 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Integrative Agriculture","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.jia.2024.07.043","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Wampee () is an important evergreen fruit tree native to southern China that has a long history of use for medicinal purposes. Here, a chromosome-level genome of was constructed with a genome size of 282.9 Mb and scaffold N50 of 30.75 Mb. The assembled genome contains 48.70% repetitive elements and 24,381 protein-coding genes. Comparative genomic analysis showed that diverged from Aurantioideae 15.91–24.95 million years ago. Additionally, some expansive and specific gene families related to methyltransferase activity and -adenosylmethionine-dependent methyltransferase activity were also identified. Further analysis indicated that -methyltransferase (NMT) is mainly involved in alkaloid biosynthesis and -methyltransferase (OMT) participates in the regulation of coumarin accumulation in wampee. This suggested that wampee's richness in alkaloids and coumarins might be due to the gene expansions of NMT and OMT. The tandem repeat event was one of the major reasons for the NMT expansion. Hence, the reference genome of will facilitate the identification of some useful medicinal compounds from wampee resources and reveal their biosynthetic pathways.
Clausena lansium 基因组为了解生物碱的多样性和甲基转移酶家族的进化提供了新的视角
黄皮()是一种重要的常绿果树,原产于中国南方,具有悠久的药用历史。本文构建的染色体级基因组大小为 282.9 Mb,支架 N50 为 30.75 Mb。组装的基因组包含 48.70% 的重复元件和 24,381 个编码蛋白质的基因。比较基因组分析表明,该物种在 1591-2495 万年前从金雀花科分化而来。此外,还发现了一些与甲基转移酶活性和-腺苷蛋氨酸依赖性甲基转移酶活性相关的广义和特异基因家族。进一步的分析表明,-甲基转移酶(NMT)主要参与生物碱的生物合成,而-甲基转移酶(OMT)则参与香豆素积累的调控。这表明芒皮中丰富的生物碱和香豆素可能是由于 NMT 和 OMT 的基因扩增造成的。串联重复事件是导致 NMT 扩增的主要原因之一。因此,参考基因组将有助于从黄皮资源中鉴定一些有用的药用化合物,并揭示其生物合成途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Integrative Agriculture
Journal of Integrative Agriculture AGRICULTURE, MULTIDISCIPLINARY-
CiteScore
7.90
自引率
4.20%
发文量
4817
审稿时长
3-6 weeks
期刊介绍: Journal of Integrative Agriculture publishes manuscripts in the categories of Commentary, Review, Research Article, Letter and Short Communication, focusing on the core subjects: Crop Genetics & Breeding, Germplasm Resources, Physiology, Biochemistry, Cultivation, Tillage, Plant Protection, Animal Science, Veterinary Science, Soil and Fertilization, Irrigation, Plant Nutrition, Agro-Environment & Ecology, Bio-material and Bio-energy, Food Science, Agricultural Economics and Management, Agricultural Information Science.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信