The I-OPTA Questionnaire: A National Assessment of Patients with Neovascular Age-Related Macular Degeneration

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-09-16 DOI:10.1007/s40123-024-01028-4

Benjamin Sommer Thinggaard, Kasper Hansen, Freja Dinesen, Maria Kjøller Pedersen, Lars Morsø, Yousif Subhi, Jakob Grauslund, Lonny Stokholm

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引用次数: 0

Abstract

Introduction

Neovascular age-related macular degeneration (nAMD) is the leading cause of irreversible vision loss in developed countries. However, a significant gap persists in understanding this population, exacerbated by their advanced age and visual impairments, which can hinder research participation and access to healthcare. The purpose of this study was to describe the content of the questionnaire and the participating patients with nAMD.

Methods

The survey includes patients diagnosed with nAMD who had previously received treatment or were currently undergoing intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. Participants were recruited using various methods, as reaching out to patients who are no longer receiving treatment poses a particular challenge. A patient and public advisory board assisted throughout the study period.

Results

Of the 713 electronic invitations sent out, 494 (69.3%) patients responded to the questionnaire, with an additional 57 responses obtained through e-mail or telephone interviews. Due to the exclusion of 16 responses, there were a total of 535 valid responses, including 176 from patients previously treated and 359 from those currently undergoing treatment for nAMD. The median age of respondents was 79.9 years (interquartile range [IQR] 75.5–84.7), with 59.8% being women. Among them, 53.2% were married, while 43.1% lived alone.

Conclusions

Data from the I-OPTA (Identification of Patient-Reported Barriers in Treatment for nAMD) questionnaire allows future exploration of patients who are no longer receiving treatment, patients’ knowledge about preventive measures, and the impact of nAMD on visual function and quality of life. Future research, including studies that integrate data from corresponding retinal images and Danish national registers, has the potential to generate invaluable knowledge, providing benefits to both patients and healthcare professionals.

Abstract Image

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I-OPTA 问卷：对新生血管性老年黄斑变性患者进行全国性评估

导言在发达国家，血管性老年黄斑变性（nAMD）是导致不可逆视力丧失的主要原因。然而，人们对这一人群的了解仍存在很大差距，他们的高龄和视力障碍更加剧了这一差距，这可能会阻碍他们参与研究和获得医疗服务。本研究的目的是描述调查问卷的内容和参与调查的 nAMD 患者。方法调查对象包括确诊为 nAMD 的患者，他们曾接受过治疗或正在接受玻璃体内抗血管内皮生长因子 (anti-VEGF) 注射。由于接触不再接受治疗的患者是一项特殊的挑战，因此采用了多种方法招募参与者。在发出的 713 份电子邀请函中，有 494 名（69.3%）患者回复了问卷，另有 57 名患者通过电子邮件或电话访谈回复了问卷。由于排除了 16 份回复，有效回复共有 535 份，其中 176 份来自曾经接受过治疗的患者，359 份来自目前正在接受 nAMD 治疗的患者。受访者的年龄中位数为 79.9 岁（四分位数间距 [IQR] 75.5-84.7），59.8% 为女性。结论 I-OPTA（患者报告的 nAMD 治疗障碍识别）调查问卷的数据有助于今后对不再接受治疗的患者、患者对预防措施的了解以及 nAMD 对视觉功能和生活质量的影响进行探讨。未来的研究，包括整合相应视网膜图像和丹麦国家登记册数据的研究，有可能产生宝贵的知识，为患者和医疗保健专业人员带来益处。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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