Testosterone and resistance training improved physical performance and reduced fatigue in frail older men: 1 year follow-up of a randomized clinical trial.

Rune Skovgaard Rasmussen,Mette Midttun,Bo Zerahn,Maria Pedersen,Anahita Rashid,Peter Busch Østergren,Tine Kolenda Paulin,Thea Winther Pødenphanth,Linda Katharina Karlsson,Eva Rosendahl,Anne-Mette Ragle,Anders Vinther,Karsten Overgaard
{"title":"Testosterone and resistance training improved physical performance and reduced fatigue in frail older men: 1 year follow-up of a randomized clinical trial.","authors":"Rune Skovgaard Rasmussen,Mette Midttun,Bo Zerahn,Maria Pedersen,Anahita Rashid,Peter Busch Østergren,Tine Kolenda Paulin,Thea Winther Pødenphanth,Linda Katharina Karlsson,Eva Rosendahl,Anne-Mette Ragle,Anders Vinther,Karsten Overgaard","doi":"10.1080/13685538.2024.2403519","DOIUrl":null,"url":null,"abstract":"OBJECTIVE\r\nTo improve health conditions among hypogonadal men ≥70 years of age using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein.\r\n\r\nMETHODS\r\nThis study is a 1-year follow-up of a double-blind RCT lasting 20 weeks, including 148 older men ≥70 years old with low testosterone levels and mobility problems. During 52 weeks, 4 groups received either testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls). Physiotherapists supported the training groups until week 20, while these participants continued trained on their own during weeks 21 to 52. The main outcome measure was the 30-s chair stand test.\r\n\r\nRESULTS\r\nThe following numbers of participants completed the trial: 20 (Combo), 20 (Controls), 24 (TU), and 14 (Training). When examining 30-s chair stand test performance within each group at baseline, and at weeks 4, 20 and 52, only the Combo group improved (p = 0.001, Friedman Test). Compared to controls, only the Combo group experienced reduced fatigue and tiredness (p < 0.05).\r\n\r\nCONCLUSIONS\r\nFifty-two weeks of testosterone supplementation combined with progressive resistance training may enhance physical performance, alleviate fatigue, and had no notable detrimental impacts among males aged ≥70 suffering from mobility issues and testosterone insufficiency.Trial registration - Clinical Trials NCT02873559.","PeriodicalId":22235,"journal":{"name":"The Aging Male","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Aging Male","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/13685538.2024.2403519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

OBJECTIVE To improve health conditions among hypogonadal men ≥70 years of age using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein. METHODS This study is a 1-year follow-up of a double-blind RCT lasting 20 weeks, including 148 older men ≥70 years old with low testosterone levels and mobility problems. During 52 weeks, 4 groups received either testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls). Physiotherapists supported the training groups until week 20, while these participants continued trained on their own during weeks 21 to 52. The main outcome measure was the 30-s chair stand test. RESULTS The following numbers of participants completed the trial: 20 (Combo), 20 (Controls), 24 (TU), and 14 (Training). When examining 30-s chair stand test performance within each group at baseline, and at weeks 4, 20 and 52, only the Combo group improved (p = 0.001, Friedman Test). Compared to controls, only the Combo group experienced reduced fatigue and tiredness (p < 0.05). CONCLUSIONS Fifty-two weeks of testosterone supplementation combined with progressive resistance training may enhance physical performance, alleviate fatigue, and had no notable detrimental impacts among males aged ≥70 suffering from mobility issues and testosterone insufficiency.Trial registration - Clinical Trials NCT02873559.
睾酮和阻力训练可改善体弱老年男性的体能表现并减轻疲劳:随机临床试验的一年随访。
目的:通过注射十一酸睾酮 (TU)、渐进式力量训练以及口服维生素 D、钙和蛋白质补充剂,改善年龄≥70 岁的性腺功能低下男性的健康状况。方法:本研究是一项为期 20 周的双盲 RCT 的 1 年随访,其中包括 148 名年龄≥70 岁、睾酮水平低且行动不便的老年男性。在为期 52 周的时间里,4 个小组分别接受了睾酮疗法(TU)或渐进阻力训练(训练)、两种疗法(组合)或无干预措施(对照组)。物理治疗师为训练组提供支持直至第 20 周,而这些参与者在第 21 至 52 周期间继续自行训练。结果完成试验的参与者人数如下:20 人(组合组)、20 人(对照组)、24 人(训练组)和 14 人(训练组)。在基线、第 4 周、第 20 周和第 52 周时,如果对各组的 30 秒椅子站立测试成绩进行检查,只有组合组的成绩有所提高(P = 0.001,弗里德曼测试)。结论52周的睾酮补充与渐进阻力训练相结合,可提高身体机能,缓解疲劳,并且对≥70岁患有行动不便和睾酮不足的男性没有明显的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信