The potential of collagen-based materials for wound management

Abstract

This review provides an overview of research on wound dressings, highlighting the potential of collagen-based materials for future wound management. Collagen, known for its biodegradability and biocompatibility, holds promise for wound healing. However, challenges such as poor mechanical properties, stability, and the lack of antibacterial properties when using collagen alone have led to the development of various solutions. The review discusses different types of collagen-based dressings, their preparation methods, and how their internal structure influences their ability to accelerate the healing of different wound types. Additionally, the article emphasizes the significant potential for the application of collagen dressings in future skin tissue engineering and in vivo tissue engineering. Specifically, three-dimensional scaffolds prepared from nanofibers through electrospinning show promise for more efficient collagen-based wound dressings, as these nanofibers have a similar extracellular matrix structure and high specific surface area, which can stimulate tissue hemostasis and promote cell adhesion, proliferation, and differentiation. However, challenges such as high production costs and poor stability in the commercial production of nanofibers need to be addressed. Overall, collagen dressings hold great promise for future applications and can play a significant role in skin tissue engineering and even in vivo tissue engineering.