Structure of small HBV surface antigen reveals mechanism of dimer formation

Xiao He, Yunlu Kang, Weiyu Tao, Jiaxuan Xu, Xiaoyu Liu, Lei Chen
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Abstract

Hepatitis B surface antigen (HBsAg), the only membrane protein on the HBV viral envelope, plays essential roles in HBV assembly, viral release, host cell attachment, and entry. It is also the target of neutralizing antibodies. Despite its functional and therapeutic importance, the detailed structure of HBsAg has remained enigmatic. Here, we present the core structure of HBsAg at 3.6 A resolution, determined using recombinant small spherical subviral particles (SVPs). The structure reveals how two HBsAg monomers interact to form a dimer, which is the basic building block of SVPs.
小型 HBV 表面抗原的结构揭示了二聚体的形成机制
乙型肝炎表面抗原(HBsAg)是乙型肝炎病毒包膜上唯一的膜蛋白,在乙型肝炎病毒组装、病毒释放、宿主细胞附着和进入过程中发挥着重要作用。它也是中和抗体的靶标。尽管 HBsAg 具有重要的功能和治疗作用,但它的详细结构一直是个谜。在这里,我们利用重组小球形亚病毒颗粒(SVPs)测定了 3.6 A 分辨率的 HBsAg 核心结构。该结构揭示了两个 HBsAg 单体如何相互作用形成二聚体,而二聚体正是 SVP 的基本组成单元。
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