One-way catalysis: Insights from a solvable lattice model

Abstract

Catalysts speed up chemical reactions with no energy input and without being transformed in the process, therefore leaving equilibrium constants unchanged. Some catalysts, however, are much more efficient at accelerating one direction of a reaction. How is such an asymmetry consistent with chemical equilibrium, where as many forward and reverse reactions must occur? We use the rigorous framework of a simple but exactly solvable lattice model to study this question in the context of a strictly one-way catalyst, which can only accelerate one way of a reaction. The model illustrates a mathematical relationship between asymmetric transition rates, which underlie directional catalysis, and symmetric transition fluxes, which underlie chemical equilibrium. The degree of directionality generally depends on the catalytic mechanism and we compare different mechanisms to show how they can obey different scaling laws. The results showcase the ability of simple physical models to address fundamental questions in catalysis.