Fabrication and characterization of nanocomposite hydrogel based N-succinyl chitosan/oxidized tragacanth gum/silver nanoparticles for biomedical materials

IF 2.7 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Atefeh Afroozan Bazghaleh, Mojtaba Akbari Dogolsar, Jalal Barzin
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Abstract

Nowadays, there is significant interest in hydrogels that have injectable, self-healing, and antibacterial properties. These features make them highly desirable for use in wound dressings. In this study, a class of biocompatible nanocomposite hydrogels was designed based on oxidized tragacanth gum (OTG), N-succinyl chitosan (NSC), and silver nanoparticles (AgNPs) for biomedical applications. To obtain the nanocomposite hydrogels containing different AgNP content, we utilized silver nanoparticles at concentrations of 4, 6, and 8 mg/mL. The OTG/NSC/Ag hydrogel demonstrated superior mechanical properties compared with the OTG/NSC hydrogel without AgNP. The hydrogels also exhibited rapid gelation ( < 60 s), sufficient swelling capacity, and outstanding injectability. The hemolysis and antibacterial tests demonstrated that the produced hydrogels possess non-hemolytic and antibacterial properties. In addition, the hydrogels loaded with AgNPs exhibited low toxicity to fibroblast cells (L929), thus demonstrating acceptable biocompatibility. These findings indicated that the prepared hydrogels could be utilized as novel wound dressing materials.

Graphical abstract

Abstract Image

用于生物医学材料的基于 N-琥珀酰壳聚糖/氧化黄胶/银纳米颗粒的纳米复合水凝胶的制备与表征
如今,人们对具有可注射、自愈合和抗菌特性的水凝胶产生了浓厚的兴趣。这些特性使它们成为伤口敷料的理想选择。在这项研究中,我们设计了一类生物相容性纳米复合水凝胶,它基于氧化甘黄胶(OTG)、N-琥珀酰壳聚糖(NSC)和银纳米粒子(AgNPs),可用于生物医学应用。为了获得含有不同AgNP含量的纳米复合水凝胶,我们使用了浓度为4、6和8毫克/毫升的银纳米粒子。与不含AgNP的OTG/NSC/Ag水凝胶相比,OTG/NSC/Ag水凝胶表现出更优越的机械性能。这些水凝胶还表现出快速凝胶化(60 秒)、足够的溶胀能力和出色的注射性。溶血和抗菌测试表明,所制备的水凝胶具有非溶血和抗菌特性。此外,负载了 AgNPs 的水凝胶对成纤维细胞(L929)的毒性较低,因此具有可接受的生物相容性。这些研究结果表明,制备的水凝胶可用作新型伤口敷料材料。
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来源期刊
Journal of Materials Research
Journal of Materials Research 工程技术-材料科学:综合
CiteScore
4.50
自引率
3.70%
发文量
362
审稿时长
2.8 months
期刊介绍: Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory
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