The XbnAb Cohort: 304 people with broadly neutralizing antibody activity to HIV-1

bioRxiv - Immunology Pub Date : 2024-09-16 DOI:10.1101/2024.09.13.612733

Chloe Pasin, Peter Rusert, Daniel Schmidt, Merle Schanz, Nikolas Friedrich, Irene A. Abela, Katharina Kusejko, Cyrille Niklaus, Michèle Sickmann, Jacqueline Weber, Michael Huber, Amapola Manrique, Andri Rauch, Alexandra Calmy, Matthias Cavassini, Marcel Stöckle, Julia Notter, Enos Bernasconi, Dominique L. Braun, Huldrych F. Günthard, Roger D. Kouyos, Alexandra Trkola, the Swiss HIV Cohort Study

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Abstract

Broadly neutralizing antibodies (bnAbs) recognizing a diversity of HIV-1 strains are widely thought to be essential for an HIV-1 vaccine. Extensive knowledge on bnAbs has been gained from studying natural HIV infection by following bnAb evolution in individual people with HIV (PWH). However, it remains essential to increase knowledge of bnAb responses in large PWH cohorts to assess the feasibility of inducing bnAb activity by vaccination. To allow a systematic analysis, we created the XbnAb cohort, a large bnAb-inducer cohort selected by screening plasma of PWH enrolled in the Swiss HIV Cohort Study (SHCS) and the Zurich Primary HIV Infection Study (ZPHI). The XbnAb cohort represents a retrospective, biobank-based cohort comprising data of 304 PWH who developed bnAb activity during HIV-1 infection. Here, we report on the characteristics of the XbnAb cohort and its potential for HIV vaccine research.

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XbnAb 群体：304 名具有广泛中和 HIV-1 抗体活性的人

人们普遍认为，识别多种 HIV-1 株系的广谱中和抗体（bnAbs）对于 HIV-1 疫苗至关重要。通过跟踪个体艾滋病病毒感染者（PWH）体内 bnAb 的演变来研究艾滋病病毒的自然感染，我们已经获得了有关 bnAb 的大量知识。然而，要评估通过接种疫苗诱导 bnAb 活性的可行性，仍然有必要增加对大型 PWH 群体中 bnAb 反应的了解。为了进行系统分析，我们创建了 XbnAb 队列，这是一个大型 bnAb 诱导队列，通过筛查瑞士艾滋病队列研究（SHCS）和苏黎世原发性艾滋病感染研究（ZPHI）中加入的 PWH 的血浆选出。XbnAb 队列是一个基于生物库的回顾性队列，由 304 名在感染 HIV-1 期间出现 bnAb 活性的 PWH 的数据组成。在此，我们将报告 XbnAb 队列的特征及其在 HIV 疫苗研究中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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bioRxiv - Immunology

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