Can Targeted Protein Degradation Technology Provide a Potential Breakthrough in the Development of Anti-AD Drugs?

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Neuroscience Pub Date : 2024-09-18 DOI:10.1021/acschemneuro.4c00590

Baichen Xiong, Zuoaoyun Song, Leyan Wang, Ao Zhang, Yu Zhou, Na Zheng, Yuqing Wei, Yao Chen, Haopeng Sun

引用次数: 0

Abstract

Recent advancements in Alzheimer’s disease (AD) research have led to the approval of lecanemab and donanemab, highlighting the effectiveness of amyloid-beta (Aβ) degradation as a treatment for AD. The prospect of small molecule Aβ degraders as a potential treatment, which utilizes emerging targeted protein degradation technology, is exciting, given their ability to address some of the limitations of current therapies and their promising future in AD treatment. Despite facing challenges, these degraders are poised to become a future treatment option, harnessing scientific breakthroughs for more targeted and effective AD therapy.

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靶向蛋白降解技术能否为抗逆转录病毒药物的开发带来潜在突破？

阿尔茨海默病（AD）研究的最新进展导致莱卡奈单抗（lecanemab）和多那奈单抗（donanemab）获得批准，凸显了淀粉样蛋白-β（Aβ）降解作为一种治疗方法的有效性。小分子Aβ降解剂利用新兴的靶向蛋白降解技术作为一种潜在的治疗方法，其前景令人振奋，因为它们能够解决目前疗法的一些局限性，而且在AD治疗中大有可为。尽管面临挑战，但这些降解剂有望成为未来的治疗选择，利用科学突破实现更有针对性、更有效的注意力缺失症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

9.20

自引率

4.00%

发文量

323

审稿时长

1 months

期刊介绍： ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research