The Clinical Utility of Finding Unexpected Subclinical Spikes Detected by High-Density EEG During Neurodiagnostic Investigations

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Clinical EEG and Neuroscience Pub Date : 2024-09-18 DOI:10.1177/15500594241284090

Michael March, Omri Bar, Madeline Chadehumbe, Kim Catterall, Mark Mintz

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Abstract

This study aimed to analyze the frequency of unexpected subclinical spikes (USCS) in pediatric patients who underwent high-density electroencephalogram (HD-EEG). Of the 4481 successful HD-EEG studies, 18.5% (829) were abnormal, and 49.7% of these abnormal studies showed SCS, of which 64.1% were USCS. USCS were found to be correlated with attention/concentration deficits and executive dysfunction, often accompanied by the dual psychiatric diagnosis of ADHD. MRI revealed abnormal findings in 32.6% of the subjects with USCS, such as abnormal signal or signal hyperintensity in brain parenchyma, temporal or arachnoid cysts, and vascular malformations. Moreover, the USCS group who received neuropsychiatric testing scored lower than the population mean on Full-Scale Intelligence Quotient, Working Memory Index, and Processing Speed Index. This study highlights the potential of USCS as biomarkers that can lead to changes in clinical management and outcomes, provide valuable information about pathophysiological mechanisms, and suggest potential treatment pathways.

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在神经诊断检查中通过高密度脑电图发现意想不到的亚临床尖峰的临床实用性

本研究旨在分析接受高密度脑电图（HD-EEG）检查的儿科患者中出现意外亚临床尖峰（USCS）的频率。在 4481 次成功的 HD-EEG 检查中，18.5%（829 次）出现异常，这些异常检查中有 49.7% 显示出 SCS，其中 64.1% 为 USCS。研究发现，USCS 与注意力/集中力缺陷和执行功能障碍相关，通常伴有多动症的双重精神诊断。32.6%的USCS受试者在磁共振成像中发现异常，如脑实质信号异常或信号强度过高、颞囊肿或蛛网膜囊肿、血管畸形等。此外，接受神经精神测试的 USCS 组在全量表智商、工作记忆指数和处理速度指数方面的得分均低于人群平均水平。这项研究强调了 USCS 作为生物标志物的潜力，它可以改变临床管理和结果，提供有关病理生理机制的宝贵信息，并提出潜在的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical EEG and Neuroscience 医学-临床神经学

CiteScore

5.20

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.