Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort.

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Elizabeth C Anderson,Helen B Foley,Joshua J Levy,Megan E Romano,Jiang Gui,Jessica L Bentz,Luis E Maldonado,Shohreh F Farzan,Theresa M Bastain,Carmen J Marsit,Carrie V Breton,Caitlin G Howe
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引用次数: 0

Abstract

Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.
MADRES 妊娠队列中的母体血糖水平与妊娠晚期循环细胞外囊泡和颗粒 miRNAs。
孕期母体高血糖会对母婴结局产生不利影响。虽然机制尚未完全明了,但母体循环 miRNA 可能在其中发挥了作用。我们研究了持续血糖水平和高血糖亚型(妊娠糖尿病、2 型糖尿病和葡萄糖不耐受)是否与妊娠晚期的循环 miRNA 相关。七个 miRNA(hsa-miR-107、hsa-let-7b-5p、hsa-miR-126-3p、hsa-miR-181a-5p、hsa-miR-374a-5p、hsa-miR-382-5p 和 hsa-miR-337-5p)与高血糖或多重测试校正前的持续血糖水平相关(p < 0.05)。这些 miRNAs 的靶基因涉及与母婴健康相关的通路,包括胰岛素信号传导、胎盘发育、能量平衡和食欲调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epigenetics
Epigenetics 生物-生化与分子生物学
CiteScore
6.80
自引率
2.70%
发文量
82
审稿时长
3-8 weeks
期刊介绍: Epigenetics publishes peer-reviewed original research and review articles that provide an unprecedented forum where epigenetic mechanisms and their role in diverse biological processes can be revealed, shared, and discussed. Epigenetics research studies heritable changes in gene expression caused by mechanisms others than the modification of the DNA sequence. Epigenetics therefore plays critical roles in a variety of biological systems, diseases, and disciplines. Topics of interest include (but are not limited to): DNA methylation Nucleosome positioning and modification Gene silencing Imprinting Nuclear reprogramming Chromatin remodeling Non-coding RNA Non-histone chromosomal elements Dosage compensation Nuclear organization Epigenetic therapy and diagnostics Nutrition and environmental epigenetics Cancer epigenetics Neuroepigenetics
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