Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Laura Ventura, Sara J. E. Verdonk, Lidiia Zhytnik, Angela Ridwan-Pramana, Marjolijn Gilijamse, Willem H. Schreuder, Kirsten A. van Gelderen-Ziesemer, Ton Schoenmaker, Dimitra Micha, Elisabeth M. W. Eekhoff
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Abstract

Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones and skeletal deformities. Individuals with OI may have dental abnormalities such as dentinogenesis imperfecta (DI) type I, malocclusions, and unerupted or missing teeth. This review comprehensively examines these dental abnormalities to assess their prevalence among the OI population and explore potential differences across different clinical types of OI and pathogenic variants. In accordance with the PRISMA guidelines, a systematic literature search in PubMed, Embase, and Web of Science was conducted that included articles up to June 2024. Out of 672 articles screened, 34 were included. The included studies confirmed that dental abnormalities are prevalent in OI, with DI prevalence ranging from approximately 20 to 48%. Those with a more severe skeletal phenotype (OI type III/IV) exhibited more dental abnormalities than those with a milder skeletal phenotype (OI type I). Notably, OI type V individuals generally do not have DI, although a few isolated cases have been reported. The prevalence of occlusion types varied: Class I occlusion ranged from 14.8 to 50% and Class II malocclusion ranged from 0 to 37.5%, while Class III malocclusion from 4.1 to 84%. This differs from the general population, where Class III malocclusion is typically the least common. Open bites, cross-bites, and unerupted and missing teeth are also commonly reported, particularly in OI types III and IV. This review emphasizes the need for comprehensive dental examinations in OI due to the high prevalence of dental abnormalities. Additionally, the review draws attention to the lack of clear guidelines for diagnosing DI.

Abstract Image

成骨不全症的牙齿异常:系统综述
成骨不全症(OI)是一种罕见的遗传性疾病,以骨骼脆弱和骨骼畸形为特征。OI 患者可能有牙科异常,如牙本质发育不全(DI)I 型、畸形、牙齿不齐或缺失。本综述全面研究了这些牙齿异常,以评估其在 OI 患者中的发病率,并探讨不同临床类型的 OI 和致病变体之间的潜在差异。根据 PRISMA 指南,我们在 PubMed、Embase 和 Web of Science 中进行了系统的文献检索,包括截至 2024 年 6 月的文章。在筛选出的 672 篇文章中,有 34 篇被纳入。所纳入的研究证实,牙齿异常在 OI 中很普遍,DI 患病率约为 20% 到 48%。骨骼表型较重(OI III/IV 型)的患者比骨骼表型较轻(OI I 型)的患者表现出更多的牙齿异常。值得注意的是,OI V 型患者一般没有 DI,但也有少数个别病例的报道。闭塞类型的发病率各不相同:I 类咬合从 14.8%到 50%不等,II 类错牙合从 0%到 37.5%不等,III 类错牙合从 4.1%到 84%不等。这与普通人群不同,在普通人群中,III类咬合不正通常是最不常见的。开合咬合、交叉咬合、牙齿未畸形和缺失也是常见报告,尤其是在 OI III 和 IV 型中。本综述强调,由于牙齿畸形的高发率,有必要对 OI 患者进行全面的牙科检查。此外,该综述还提请注意缺乏诊断 DI 的明确指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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