Off‑label and unapproved pediatric drug utilization: A meta‑analysis.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Xingxing Yuan,Jiawei Gao,Liuxin Yang,Yurong Tan,Ousman Bajinka
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Abstract

Despite legislative enforcement on authorized drugs, off-label and unapproved pediatric drug use is prevalent. The present study aimed to assess the global prevalence of off-label and unlicensed prescriptions among hospitalized children via meta-analysis. A comprehensive examination of articles published between 1990 and 2023 from the PubMed, Scopus, Excerpta Medica Database, Web of Science and Google Scholar databases was conducted. Key word-based advanced searches were executed using the aforementioned databases. A total of 45 studies that reported the prescriptions of off-label and unlicensed drugs to pediatric patients were included. The global prevalence of off-label and unlicensed drug prescriptions to children in pediatrics or neonatal departments was 56%. Patient sample sizes varied from 40-13,426, with a range of 240-8,891 total prescriptions issued. Of the 45 studies examined, 22 studies originated from Europe, 13 from Asia, 3 from South America, 3 from Africa, and 2 each from North America and Australia. Africa had the highest prevalence rate at 66%, followed by Asia, South America, North America, Australia and Europe. The present meta-analysis demonstrated that the prevalence of off-label and unlicensed drug prescriptions given to pediatric patients was notably high and geographically diverse. Therefore, drug authorities should standardize pediatric prescription practices in future.
标示外和未经批准的儿科用药:荟萃分析。
尽管立法机构对授权药物进行了强制执行,但标示外和未经批准的儿科药物使用仍十分普遍。本研究旨在通过荟萃分析评估全球住院儿童标示外和未经许可处方的流行情况。研究人员对 PubMed、Scopus、Excerpta Medica Database、Web of Science 和 Google Scholar 数据库中 1990 年至 2023 年间发表的文章进行了全面研究。利用上述数据库进行了基于关键词的高级检索。共纳入了 45 项报告儿科患者处方标示外和无证药物的研究。儿科或新生儿科对儿童开具标示外和无证药物处方的总体发生率为 56%。患者样本量从 40-13,426 例不等,处方总数从 240-8,891 例不等。在 45 项研究中,22 项来自欧洲,13 项来自亚洲,3 项来自南美,3 项来自非洲,北美和澳大利亚各 2 项。非洲的流行率最高,为 66%,其次是亚洲、南美洲、北美洲、澳大利亚和欧洲。本荟萃分析表明,儿科患者标示外和无证用药处方的发生率明显偏高,且地域差异较大。因此,药品管理部门今后应规范儿科处方做法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
期刊介绍:
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