Toxic Effects in Subsequent Generations from Sex-Dependent Exposure to 2,3ꞌ,4,4ꞌ,5-Pentachlorobiphenyl (PCB 118) on Danio rerio

IF 0.8 4区 生物学 Q4 MARINE & FRESHWATER BIOLOGY
D. A. Kotsur, A. P. Novoselov, T. Yu. Sorokina, A. S. Aksenov, V. P. Chashchin
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Abstract

The results of an experiment on the oral exposure of polychlorinated biphenyl (PCB) 118 into the zebrafish Danio rerio (Hamilton, 1822) (F0) with food at calculated doses of 5, 20, and 80 μg/individuals are presented. In the first generation F1, there is a decrease in survival rate and a shift in the sex ratio, predominantly towards females. In the second generation F2, the same effects are noted as in F1, but they are not as pronounced. It has been hypothesized that the effects seen in the F2 generation may be caused by epigenetic mechanisms, which are still poorly understood. It is possible that the feminization of animal populations and a decrease in their survival rate are very strong factors in reducing the populations of living organisms, including humans, especially near sites of distribution of PCBs. It is necessary to study epigenetic mechanisms in order to develop measures to eliminate and prevent problems with the biotic degradation and depopulation of fish exposed to PCBs in the sites that arise as a result of the improper disposal of electrical engineering waste containing PCBs.

Abstract Image

暴露于 2,3ꞌ,4,4ꞌ,5-五氯联苯(PCB 118)对丹利鱼后代的毒性影响与性别有关
摘要 本文介绍了斑马鱼 Danio rerio(Hamilton,1822 年)口服多氯联苯(PCB)118(F0)的实验结果,食物的计算剂量为 5、20 和 80 微克/个体。在第一代 F1 中,存活率下降,性别比例发生变化,主要偏向雌性。在第二代 F2 中,发现了与 F1 相同的影响,但并不明显。据推测,F2 代中出现的影响可能是由表观遗传机制造成的,但人们对这种机制还不太了解。动物种群的雌性化和存活率的下降可能是导致生物种群(包括人类)减少的重要因素,尤其是在多氯联苯的分布地点附近。有必要对表观遗传学机制进行研究,以便制定措施,消除和防止由于含有多氯联苯的电 气工程废物处置不当而造成的生物退化和鱼类接触多氯联苯后数量减少的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inland Water Biology
Inland Water Biology 生物-海洋与淡水生物学
CiteScore
1.30
自引率
55.60%
发文量
87
审稿时长
6-12 weeks
期刊介绍: Inland Water Biology publishes thematic reviews and original papers devoted to flora and fauna in waterbodies, biodiversity of hydrobionts, biology, morphology, systematics, ecology, ethology, ecological physiology and biochemistry of aquatic organisms, patterns of biological cycle, structure and functioning of aquatic ecosystems, anthropogenic and uncontrolled natural impacts on aquatic organisms and ecosystems, invasion of nonindigenous species into ecosystems and their ecology, methods of hydrobiological and ichthyological studies.
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