Excimer Light versus Combination of Tacrolimus and Excimer Light in the Treatment of Alopecia Areata

IF 3.7 4区 医学 Q1 DERMATOLOGY
Nashwa Mostafa Mohammed, Maha Rafie Hassan, Nevien Ahmed Samy, Ahmed Saeed Aladl, Ayman Farag Abdelaziz Dawa, Shady Mahmoud Attia Ibrahim
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Abstract

Background. Alopecia areata (AA) is a nonscarring alopecia that can affect any hairy area of the body. Excimer light at 308 nm with immunosuppressive effects is recommended as a promising management method for AA. Objectives. To assess the efficacy and safety of excimer light at 308 nm alone versus a combination of tacrolimus 0.1% and excimer light in the treatment of alopecia areata. Methods. Forty patients with AA of the scalp were divided into two groups, group A was treated with an excimer lamp twice per week for three months, and group B was treated with a combination of tacrolimus 0.1% and an excimer light. The efficacy of the treatment was evaluated by the SALT score and serum T-regulatory cells at the baseline, after 3 months from the baseline, and after 6 months from the beginning of treatment. Results. In group (A), the median SALT decreased from the baseline (13.15) to (6.15) 3 months after the baseline and further decreased after 6 months of follow-up to (3.3). While in group (B), the median SALT score was decreased from the baseline (11.15) to (0.5) after 6 months from the beginning of treatment. After 3 months, there was improvement in Treg function in both groups A and B (4.98 ± 1.02, 5.50 ± 0.84), respectively. There was a significantly higher improvement in group B (85.19 ± 8.55) than group A (70.05 ± 9.95). Dermoscopic findings reveal decreased signs of activity in group B more than group A. Conclusion. The combination of excimer light and tacrolimus is more effective than excimer light alone in treatment of AA.

Abstract Image

准分子光与他克莫司和准分子光联合治疗脱发症的比较
背景。斑秃(AA)是一种非瘢痕性脱发,可影响身体任何有毛发的部位。具有免疫抑制作用的 308 纳米准分子光被推荐为治疗 AA 的一种有前途的方法。研究目的评估单独使用 308 纳米准分子光与联合使用 0.1% 他克莫司和准分子光治疗斑秃的有效性和安全性。治疗方法将 40 名头皮 AA 患者分为两组,A 组接受准分子光治疗,每周两次,为期三个月;B 组接受 0.1% 他克莫司和准分子光联合治疗。通过基线、基线后 3 个月和治疗开始后 6 个月的 SALT 评分和血清 T 调节细胞来评估疗效。结果显示在(A)组中,SALT 中位数从基线(13.15)下降到基线3个月后的(6.15),随访6个月后进一步下降到(3.3)。而在(B)组中,SALT 的中位数从基线(11.15)下降到治疗开始 6 个月后的(0.5)。3 个月后,A 组和 B 组的 Treg 功能均有所改善(分别为 4.98 ± 1.02、5.50 ± 0.84)。B 组的改善程度(85.19 ± 8.55)明显高于 A 组(70.05 ± 9.95)。皮肤镜结果显示,B 组比 A 组活动迹象更少。准分子光与他克莫司联合治疗 AA 比单独使用准分子光更有效。
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来源期刊
Dermatologic Therapy
Dermatologic Therapy 医学-皮肤病学
CiteScore
7.00
自引率
8.30%
发文量
711
审稿时长
3 months
期刊介绍: Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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